We studied the role of acetylcholine (ACh) in creating learning-related long-lasting modifications in the rat cortex. Rats were trained to discriminate positive and negative cues in pairs of odors, until they demonstrated rule learning and entered a mode of high capability for learning of additional odors. We have previously reported that pyramidal neurons in olfactory (piriform) cortex from tr...

Memory acquisition and synaptic plasticity are accompanied by changes in the intrinsic excitability of CA1 pyramidal neurons. These activity-dependent changes in excitability are mediated by modulation of intrinsic currents which alters the responsiveness of the cell to synaptic inputs. The afterhyperpolarization (AHP), a major contributor to the regulation of neuronal excitability, is reduced ...

Acupoint herbal patching (AHP), which involves local point stimulation with a herbal medicine patch, has long been used to treat patients with asthma in East Asian countries. However, its evidence is equivocal. This systematic review aims to summarize and critically evaluate the efficacy and safety of AHP for asthma.A literature search was conducted in PubMed, EMBASE, the Cochrane library, and ...

M-current (I(M)) is a voltage-gated potassium current (KCNQ type) that affects neuronal excitability and is modulated by some drugs of abuse. Ventral tegmental area (VTA) dopamine (DA) neurons are important for the reinforcing effects of drugs of abuse. Therefore we studied I(M) in acutely dissociated rat DA VTA neurons with nystatin-perforated patch recording. The standard deactivation protoco...

Group decision making is an important part of multiple criteria decision making and the analytic hierarchy process (AHP). The aim of this paper was to compare group AHP methods. Seven simple group AHP aggregation techniques that could be attractive for applications selected from the vast array of group AHP models proposed in the literature were selected for evaluation. We developed three new me...

“The theory of decision analysis (DA) is designed to help the individual make a choice among a set of prespecified alternatives” (Keeney and Raiffa 1976, vii). Simply put, the basic DA problem is, How should a decision maker select from a given set of competing alternatives that are evaluated against conflicting objectives? Because operations research (OR) is the science of decision making, OR ...

This paper presents a two-dimensional approximately harmonic projection (2DAHP) algorithm for gait recognition. 2DAHP is originated from the approximately harmonic projection (AHP), while 2DAHP offers some advantages over AHP. 1) 2DAHP can preserve the local geometrical structure and cluster structure of image data as AHP. 2) 2DAHP encodes images as matrices or second-order tensors rather than ...

introduction: ground water as a dynamic and recyclable natural resource in fractured rock terrains are characterized by single and double fracture porosity models. due to the heterogeneous nature of the medium hydraulic properties of these rocks are mainly controlled by fracturing and influenced by multivariate parameters. this heterogeneity is due to various compactions , density of fractures ...