BACKGROUND The purpose of this study was to evaluate the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlation in hypopharyngeal cancer. METHOD We retrospectively reviewed the medical records of 57 patients who underwent FDG PET/CT for hypopharyngeal cancer. RESULTS ECS was present in...

Radioresistance remains a major problem in the treatment of patients with hypopharyngeal squamous cell carcinoma (HSCC). Long noncoding RNAs (lncRNAs) have important roles in the development, invasion, and metastasis of various tumors, including HSCC, but little is known about the role of lncRNAs in cancer radioresistance. The aim of this study was to identify radioresistance-related lncRNAs an...

BACKGROUND For larynx preservation, radiotherapy is gaining popularity for primary treatment of laryngeal and hypopharyngeal cancer, reserving surgery for salvage. OBJECTIVE To analyze the outcome of salvage surgery after failure of primary radiotherapy. DESIGN Nine-year retrospective outcome analysis. SETTING University referral center. PATIENTS Fifty-four patients with squamous cell c...

yngectomy for laryngeal cancer 3 years earlier was diagnosed with superficial esophageal squamous cell carcinoma (ESCC). In addition, a slightly elevated le− sion (1.6 cm) was detected synchronously in the posterior wall of the hypopharynx (l" Fig. 1 a). Using a narrow−band ima− ging (NBI) system with magnifying en− doscopy (GIF TYPE H260Z; Olympus), this lesion displayed a clearly demarcated b...

BACKGROUND/AIMS The efficacy of surveillance for esopha-geal squamous cell neoplasia (ESCN) in patients with head and neck squamous cell carcinoma (HNSCC) remains contro-versial. Our study aimed to provide clinical data concerning the necessity of surveillance for detecting early ESCN in pa-tients with HNSCC. METHODS We retrospectively reviewed the data from 714 patients who were pathological...

BACKGROUND Despite the demonstrated survival equivalence between chemoradiation and ablative surgery as primary treatment for advanced laryngeal and hypopharyngeal cancers, a subset of patients who undergo organ-preservation therapy have persistent tracheostomy requirement after completion of treatment. METHODS Patients who received primary chemoradiation for advanced laryngeal or hypopharyng...

This study aimed to determine the expression of integrin β1 and vascular endothelial growth factor (VEGF) and microvascular density (MVD) by CD105 staining in hypopharyngeal squamous cell carcinoma to determine their association with clinicopathologic characteristics, and to determine their role and the effects of their interactions in the development and progression of hypopharyngeal squamous ...

The treatment of head and neck cancer has traditionally consisted of surgery with postoperative radiation therapy. Chemotherapy has been reserved for palliation. In recent years, induction chemotherapy has been shown to allow for larynx preservation in patients with laryngeal or hypopharyngeal cancer. Concomitant chemoradiotherapy has been shown to provide a statistically significant survival b...