The present review discusses the hemodynamic and immune-modulatory effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline applicable to severe sepsis and septic shock are highlighted. Data available support potential benef...

Study objectives: Hypertonic saline solution inhalation is suspected to produce airway inflammation. Design: The aim of this study was to verify this hypothesis by measuring inflammatory markers in exhaled breath condensate (EBC) collected before and after sputum induction with hypertonic and isotonic saline solution. Patients and methods: We enrolled 10 patients with asthma, 10 patients with C...

PURPOSE This study was done to examine the effects of 4% hypertonic saline solution mouthwash and tooth brushing education on the oral health of elders living in long term care facilities. METHODS In this quasi-experimental study, the participants were assigned to a 2% experimental group (n=20), a 4% experimental group (n=20), and a control group (n=20). Data were analyzed using ANOVA, repeat...

Continuous hypertonic saline for hemispheric ischemic infarcts has been routinely used in neurocritical centers the management of malignant cerebral edema. However, data supporting its use are extremely limited. We present a systematic literature review that highlights five studies (one randomized control trial and four retrospective cohort) where effects continuous were studied patients with a...

The article summarizes the literature on use of N-acetylcysteine and its combination with 3% NaCl solution (FLU-ACYL broncho) in clinical practice. Studies show that is currently effective treatment respiratory diseases due to multicomponent effects system immune system. Hypertonic (3%) potentiates action by inhalation allows achieve good results acute chronic optimal time. One well-known Ukrai...

The effect of hypertonicity on the electrical properties of vertebrate myocardial cells was studied in ventricular muscle fibers of guinea pig, cat, frog, and chicken. The latter two species do not have a T-tubule system, whereas the former two do. In hypertonic solutions (2 x isotonic) produced by addition of sucrose or excess of NaCl, cell diameter decreased and there was a slight hyperpolari...

In the neurocritical care setting, hyponatremia is the commonest electrolyte disorder, which is associated with significant morbimortality. Cerebral salt wasting and syndrome of inappropriate antidiuretic hormone have been classically described as the 2 most frequent entities responsible of hyponatremia in neurocritical care patients. Nevertheless, to distinguish between both syndromes is usual...

High-throughput genomic technology has enabled us to screen the entire genome and generate hypotheses at relatively low costs. One of the driving forces in highthroughput genomic technology is high-throughput sequencing (HTS).With its rapid development and affordability, HTS has quickly become the go-to choice for interrogating the entire genome. The analysis methodology development for HTS has...

We studied two neonates fed diluted formula and excessive water who developed hyponatraemic convulsions; treatment included intravenous hypertonic saline and water restriction. Educating mothers is important to stop recurrences.