imbalance due to peritoneal irritation which leads to sequestration of fluid, electrolyte and colloid in the adynamic, distended intestine, leading eventually to severe acidosis. The present case is a good example of this electrolyte imbalance, i.e. hyperkalaemia, hypernatraemia, uraemia and acidosis. This bizarre biochemical picture is a helpful pointer to the diagnosis when an emergency retro...

We describe a 30 year old man who developed chronic adipsic hypernatraemia and hypothermia following a subarachnoid haemorrhage from an anterior communicating artery aneurysm. Anterior pituitary function tests were normal. Hypothermia was demonstrated over 4 years with loss of the ability to control heat conservation despite body temperatures as low as 30 degrees C. He failed to experience thir...

The paper describes the first controlled trial of an oral glucose electrolyte solution designed on basis optimum pathophysiological needs for rehydration in infantile diarrahoea. solution, having a sodium concentration 50 mmol/l, was tried group 20 infants with moderate to severe dehydration due acute diarrhoea and compared matched 19 predominantly under 2 years age taking 9standard9 90 mmol/l....

AIMS To describe incidence, presentation, treatment and short term outcomes of severe neonatal hypernatraemia (SNH, sodium ≥160 mmol/l). METHODS Prospective, population based surveillance study over 13 months using the British Paediatric Surveillance Unit. Cases were >33 weeks gestation at birth, fed breast or formula milk and <28 days of age at presentation. RESULTS Of 62 cases of SNH repo...

Disturbances in salt and water balances are relatively common in children after brain surgeries for suprasellar and pituitary tumours, presenting diagnostic and therapeutic challenges. Although hypernatraemia associated with central diabetes insipidus is commonly encountered, it is hyponatraemia (HN) that poses more of a diagnostic dilemma. The main differential diagnoses causing HN are the syn...