BACKGROUND Canine babesiosis, caused by Babesia canis, is a prevalent and clinically relevant disease in Europe. Severe acute babesiosis is characterized by a high mortality but prognosis is not always correlated with clinical signs nor with the level of parasitemia. OBJECTIVE This study evaluated prognostic markers associated with poor outcomes in acute Babesia canis infections. ANIMALS AN...

Cardiovascular failure or shock, of any etiology, is characterized by ineffective perfusion of body tissues, inducing derangements in the balance between oxygen delivery and consumption. Impairment in oxygen availability on the cellular level causes a shift to anaerobic metabolism, with an increase in lactate and hydrogen ion production that leads to lactic acidosis. The degree of hyperlactatem...

The use of epinephrine in septic shock remains controversial. Nevertheless, epinephrine is widely used around the world and the reported morbidity and mortality rates with it are no different from those observed with other vasopressors. In volunteers, epinephrine increases heart rate, mean arterial pressure and cardiac output. Epinephrine also induces hyperglycemia and hyperlactatemia. In hyper...

Nucleoside reverse transcriptase inhibitors (NRTIs) form important component of antiretroviral therapy (ART) regimens for HIV/AIDS patients in low income countries. These drugs, especially stavudine can induce potentially life threatening lactic acidosis. It is very important to detect the early symptoms of lactic acidosis so that the life of the patient can be saved by prompt withdrawl of ART ...

Both in emergency and elective surgical patients increased blood lactate levels warn the physician that the patient is at risk of increased morbidity and decreased changes of survival. Prompt therapeutic measures to restore the balance between oxygen demand and supply are warranted in these patients.

An increased basal plasma lactate concentration is present in many physiological and pathological conditions, including obesity and diabetes. We previously demonstrated that acute lactate infusion in rats produced a decrease in overall glucose uptake. The present study was carried out to further investigate the effect of lactate on glucose transport and utilization in skeletal muscle. In chroni...

BACKGROUND Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis. METHODS In a cohort of patients with falciparum malaria hospitalized in Chittagong, Bangladesh, bulk RCD was measured using a laser diffracti...

BACKGROUND Patients with sepsis admitted to the intensive care unit often present with acid-base disorders. As the traditional interpretation might be clinically misleading, an alternative approach described by Stewart may allow one to quantify the individual components of acid-base abnormalities and provide an insight into their pathogenesis. The aim of our study was to compare the traditional...

A previously healthy 5-year-old, female, spayed, mixed breed dog presented for acute abdominal distension and non-productive retching after consuming a large volume of kibble food. Abdominal radiographs confirmed food engorgement, standard medical therapy was initiated with intravenous fluids analgesics. After 36 hours persistent progressive hyperlactatemia, an exploratory laparotomy revealed g...