We report a case of liver damage in an elderly patient after the use of herbal products of Hypericum perforatum and copaiba (Copaifera langsdorffii Desf). Hepatotoxicity related to Hypericum perforatum is anecdotally known, but for copaiba, widely used as anti-inflammatory, there is just experimental data in the national literature. This report aimed to draw attention to the possible toxic effe...

abstractparkinson’s disease (pd) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of pd in rat. for this purpose, unilateral ...

Amaç: Bitkilerden elde edilen uçucu yağlar, geleneksel sentetik böcek öldürücülere çevre dostu alternatifler sağlayabilir. Bu çalışmada beş farklı esansiyel yağın (Thymus vulgaris, Piper nigrum, Syzygium aromaticum, Hypericum perforatum, Papaver somniferum) Musca domestica larvalarına karşı etkisinin değerlendirilmesi amaçlanmıştır. Yöntem: Her yağ çeşidinin üç dozu (% 1, % 3 ve 6) tekerrürlü o...

Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials ...

BACKGROUND AND AIMS Hypericum perforatum (St. John's wort) is a widespread Eurasian perennial plant species with remarkable variation in its morphology, ploidy and breeding system, which ranges from sex to apomixis. Here, hypotheses on the evolutionary origin of St. John's wort are tested and contrasted with the subsequent history of interspecific gene flow. METHODS Extensive field collection...

ABSTRACT Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disorder with massive loss of dopaminergic neurons in the substantia nigra pars compacta. L-Dihydroxyphenylalanine (L-DOPA) substitution is still the gold standard therapy for PD. However, there has been little information available on neuroprotective and regenerative therapies for PD. Due to the neu...

introduction: motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. this study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. methods: neonate rats (n=56) were randoml...

In the rat several paradigms of grafting of adrenal medulla into the striatum were studied following the induction of a parkinsonian model, using a unilateral 6-hydroxydopamine (6-OHDA) lesion of the substantia nigra. Direct autologous grafting of adrenal medulla into the caudate-putamen complex, a radiofrequency lesion of the striatum alone, and a radiofrequency lesion followed by delayed graf...

Introduction: Motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. This study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. Methods: Neonate rats (n=56) were rand...

background: dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as iran. objective: the aim of this study was determining the antifungal effect of hypercom perforatum essential oil. methods: the minimum inhibitory concentration (mic) and minimum fungicidal concentration (mfc) for the essential oil of the plant...