Chemoreceptor discharges were recorded from the carotid sinus nerve of the cat in vivo, and their frequency was used as an index of receptor activity. The effects of dopamine on chemoreceptor activity were analyzed in normal and ischemic carotid bodies. Intra-arterial injections of dopamine (DA) induced various patterns of chemoreceptor responses; simple inhibition, inhibition followed by excit...

Growth of C-1300 neuroblastoma was markedly suppressed in mice chemically sympathectomized at birth with 6-hydroxydopamine. Growth of A-10 adenocarcinoma was also somewhat reduced. In newborn mice pretreated with nerve growth factor to induce sympathetic nervous system neuronal hypertrophy, neuronal maturation, and peripheral hyperinnervation, the growth of neuroblastoma was augmented.

The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the ...

background and objective: parkinson's disease (pd) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. l-dihydroxyphenylamine (l-dopa) therapy is currently the gold standard maneuver for pd. due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of thi...

Previous results suggest that the tryptophan metabolite, picolinic acid may have the unusual properties of antagonizing the neurotoxic but not the neuroexcitant effects of another tryptophan metabolite, quinolinic acid in the central nervous system. The present experiments tested this possibility utilizing behavioural and tyrosine hydroxylase immunohistochemical techniques. In the first series ...