Abstract This study describes the preparation, physicochemical characterization and biological studies of polymeric delivery systems proanthocyanidins (PCAN) extracted from Pelargonium sidoides for potential use as wound dressings. In this 20 wt% PCAN demonstrated good antimicrobial activity against Staphylococcus aures, a gram-positive pathogen. Poly(D,L-lactide) atactic poly[(R,S)-3-hydroxybu...

D-(-)-3-Hydroxybutyrate (DHB), the immediate depolymerization product of the intracellular carbon store poly-3-hydroxybutyrate (PHB), is oxidized by the enzyme 3-hydroxybutyrate dehydrogenase to acetoacetate (AA) in the PHB degradation pathway. Externally supplied DHB can serve as a sole source of carbon and energy to support the growth of Sinorhizobium meliloti. In contrast, wild-type S. melil...

Poly(3-hydroxybutyrate) (PHB) is a polyester of 3-hydroxybutyric acid (HB) that is ubiquitously present in all organisms. In higher eukaryotes PHB is found in the length of 10 to 100 HB units and can be present in free form as well as in association with proteins and inorganic polyphosphate. It has been proposed that PHB can mediate ion transport across lipid bilayer membranes. We investigated ...

For the development of a resorbable gastrointestinal patch, the in vitro degradation of solution-cast films of poly(3-hydroxybutyrate) (PHB), modifications of PHB expected to influence its degradation time, as well a poly(L-lactide) (PLLA) was examined. The molecular weight of pure PHB decreased by one-half after 1 year in buffer solution (pH 7.4, 37 degrees C). Acceleration in molecular weight...

The present work reported the preparation of biocomposites based on poly(3-hydroxybutyrate) (PHB), plasticizer, and bacterial cellulose (BC) by melt processing their testing means thermal properties (DSC), water absorption, in vitro degradation. surface was analyzed via atomic force microscopy (AFM). In degradation evaluated weight loss (DSC) assessment after immersion specimens phosphate-buffe...

Biochar is an excellent, but less-used candidate to serve as alternative filler in poly(3-hydroxybutyrate) (PHB)-based composites. Increasing amounts of biochar between 20 and 50 wt% were incorporated PHB/char PHB/thermoplastic starch (TPS)/char composites its effects on the microstructure, crystallization thermal properties investigated. PHB shows a significant reduction molecular weight after...

New microbial bioprospecting has become an important way to find new polyhydroxyalkanoate (PHA) producers and degraders. Poly (3-hydroxybutyrate) (PHB), the best known member of the PHAs, has received much attention because it can be degraded completely in different environments without forming any toxic products. In this contribution an actinomycete, designated strain SSM 5670, showed the bett...

Biodegradable polymeric materials can be used as temporary implants and may be able to carry out specific functions for a pre-determined period prior to their degradation in vivo. In order to be used they must present characteristics of biocompatibility. When a material comes into contact with blood, the instantaneous adsorption of protein occurs on its surface. Coverage of the surface by γ-glo...

Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications. Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of n...