A novel binary compounds as 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-phenyl-2H-benzo[f]indazole-4,9-dione (10) and fused 2-hydroxy-3-(4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)naphthalene-1,4-dione (7) naphtho[2,3-b]furan-3,4,9(2H)-trione (6) based on lawsone ‘that plays important precursor’ was synthesized by reaction with 1,3-diphenyl-1H-pyrazole-4-carbaldehyde halo-compounds, such 2-chlor...

This study highlights the potential of ?-hydroxy amines as building blocks for aza-Michael CANs.

five new 1-hydroxy-2-(1-alkyloxymethyl)-9,10-anthraquinones (9a-e) have been prepared. selective nitration of 2-methyl-9,10-anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-2-methyl-9,10-anthraquinone in good yield as the key intermediate. reaction with dimethylsulphate/k2co3 and subsequent monobromination with nbs...

Case presentation: Male patient, 6 months old, admitted due to seizure associated with severe refractory hypoglycemia. Patient had been experiencing unusual sleepiness for 8 days, and vomiting after feedings. Brain CT showed prominence of the bilateral frontotemporal extra-axial space Sylvian fissures, EEG revealed a slow diffuse moderate disturbance background activity MRI extensive areas diff...

Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8-(4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-...

Background and Aims: 25-hydroxy vitamin D3 is recognized to be an essential element for healthy body; however, its deficiency has been identified as a risk factor for thyroid disease, diabetes mellitus and other autoimmune diseases and infectious diseases. Thyroid disease is common in the general population that its prevalence increases proportional to age. Subjects with poorly controlled diabe...

Eight adducts were characterized from the reaction of deoxycytidine with the chemical carcinogen, butadiene monoxide (BM). They were identified as diastereomeric pairs of N3-(2-hydroxy-3-buten-1-yl)deoxycytidine, N3-(2-hydroxy-3-buten-1-yl)deoxyuridine, N3-(1-hydroxy-3-buten-2-yl)deoxyuridine, and O2-(2-hydroxy-3-buten-1-yl)deoxycytidine based on UV spectra, 1H NMR, FAB/MS, and stability studie...

AHAs act on both the epidermal and the dermal levels. When applied to the skin, AHAs stimulate the exfoliation of epidermal cells in the stratum corneum (s.c.) by interfering with the ionic bonding between these cells. This results in the sloughing off dull, rough skin and promotes cellular renewal. Initially used for treatment of hyperkeratosis and other skin conditions affecting s.c. turnover...

The leaves and bark of Ficus sagittifolia have been used as a cure for stomach pulmonary disorders, respectively. is edible taken against colic. From the F. sagittifolia, steroidal glycoside named Stigmast-5,22-diene-3-O-β-D-glucopyranoside 1 three isoflavonoids 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 2, 5-hydroxy-3(4-hydroxylphenyl)-8,8-dimethylpyrano[2,3-f]-chromen-4(8H)-one ...