311 ©2011 Society For Biomaterials

Hydrogels have found promising applications in drug delivery due to their biocompatibility, high drug loading capability, and tunable release profiles. However, hydrogel-based carriers are primarily employed for delivering hydrophilic payloads while hydrophobic drugs cannot be efficiently delivered due to the lack of hydrophobic domains within conventional hydrogel matrices. Herein, we report t...

Sulfuric acid-catalyzed hydrolysis of cellulose commonly isolates nanocrystals (CNCs). Neutralizing the reactant solution with sodium hydroxide facilitates efficient downstream processing, but residual salt remains in product. This study examines reinforcing effects CNCs from suspensions that contain on mechanical properties thermoplastic starch nanocomposites. By films up to 5 wt% CNCs, stiffn...

The generation of tribo-electric charge during pharmaceutical powder processing can cause a range of complications, including segregation of components leading to content uniformity and particle surface adhesion. This phenomenon becomes problematical when excipients are introduced to a powder mixture alongside the highly charging active pharmaceutical ingredient(s) (APIs). The aim of this study...

Oral dosage forms containing 300 mg theophylline in matrix type tablets, were prepared by direct compression method using two kinds of matrices, glycerylbehenate (hydrophobic), and (hydroxypropyl)methyl cellulose (hydrophilic). The in vitro release kinetics of these formulations were studied at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution ...

Drug release mechamsms of swellable systems for controlled drug administration were investigated The variations of the matrix relaxation and drug diffusion rates were quantified, by measuring the surface area exposed during matrix swelling and drug release as a function of impermeable coating coverage and location. Four different types of matrices, partially coated on various sides, were invest...

Hypromellose, HPMC, is frequently used to control drug release from matrix tablet formulations. Drug is released by a combination of diffusion through and erosion of, the matrix and is usually measured invitro by separate dissolution and swelling/erosion studies. The present study was designed to measure matrix erosion, polymer dissolution and drug release kinetics and their inter-relationship ...

Brane world cosmologies seem to provide an alternative explanation for the present accelerated stage of the Universe with no need to invoke either a cosmological constant or an exotic quintessence component. In this paper we investigate statistical properties of gravitational lenses for some particular scenarios based on this large scale modification of gravity. We show that a large class of su...