PURPOSE Increased blood-brain barrier (BBB) permeability is radiologically detectable in regions affected by drug-resistant epileptogenic lesions. Brain penetration of antiepileptic drugs (AEDs) may be affected by BBB damage. We studied the effects of BBB damage on brain distribution of hydrophilic [deoxy-glucose (DOG) and sucrose] and lipophilic (phenytoin and diazepam) molecules. We tested th...

Xenobiotic metabolism involves the biochemical modification of drugs and phytochemicals in living organisms, including humans and other animals. In the intestine, the gut microbiota catalyzes the conversion of hydrophilic drugs into absorbable, hydrophobic compounds through hydroxyzation and reduction. Drugs and phytochemicals are transformed into bioactive (sulfasalazine, lovastatin, and ginse...

Xenobiotic metabolism involves the biochemical modification of drugs and phytochemicals in living organisms, including humans and other animals. In the intestine, the gut microbiota catalyzes the conversion of hydrophilic drugs into absorbable, hydrophobic compounds through hydroxyzation and reduction. Drugs and phytochemicals are transformed into bioactive (sulfasalazine, lovastatin, and ginse...

Cancer Immunotherapy In article number 2210986, Mingming Ding and co-workers construct a photoallosteric polymersome (PAP) that undergoes rapid conformational transition from β-sheet to α-helix upon exposure near-infrared light irradiation. Photoinduced allosteric behavior specifically enhances cell penetration lysosome escape reconstructs the vesicular membrane structure for on-demand release ...

purpose : to report clinical and pathological features of three cases of opacification with hydrophilic acrylic intraocular lenses (iols) case reports : in this interventional case report, we introduce the surgical and laboratory information about three hydrophilic acrylic iols which calcified after implantation for these patients with cataract. these lenses were explanted and analyzed with opt...

Despiteadvancements in wound management, chronic wounds still fail to heal anappropriate time and manner. Hydrophobic drugs of interest the pharmaceuticalindustry exist that are suggested reduce inflammation aid woundhealing process; however, delivering these poses a challenge both interms ease formulation processing drug release characteristics whenapplied vivo. Naturally occurring, biocompati...

The apparent volume of distribution was defined for the first time as phase that can hold total amount a substance at measured concentration, in system composed two immiscible media are contact under conditions constant volumes, equilibrium. Its value is not affected by solute mass and it only depends on volume, volumes affinity phases system. Using this new concept distribution, we were able t...

The transdermal drug delivery system is an alternative method of administration drugs. Most the drugs are delivered by conventional oral, topical, intravenous, and intramuscular methods limited efficiency. However, now clinical use because stratum cornea skin act as effective barrier that limits permeation through skin. To overcome this disadvantage, there Recent developments in delivery, such ...

Solid Lipid Nanoparticles (SLNs) have gained significant attention in recent years as a promising delivery system for drugs targeting the Central Nervous System (CNS) via Nose-To-Brain (NTB) route. The unique characteristics of SLNs, such their small particle size, high stability, and ability to encapsulate lipophilic drugs, make them suitable crossing Blood Brain Barrier (BBB) achieving target...