The active ingredients of salvia (dried root of Salvia miltiorrhiza) include both lipophilic (e.g., tanshinone IIA, tanshinone I, cryptotanshinone and dihydrotanshinone I) and hydrophilic (e.g., danshensu and salvianolic acid B) constituents. The low oral bioavailability of these constituents may limit their efficacy. A solid self-microemulsifying drug delivery system (S-SMEDDS) was developed t...

The purpose of this study was to characterize the non-aqueous nanosuspension of a hydrophilic drug prepared by bead milling for cutaneous application. Riboflavin was used as the model hydrophilic drug. The non-aqueous nanosuspensions were prepared by grinding riboflavin with zirconia beads using eight non-aqueous bases. The mean particle size of riboflavin in the suspensions ranged from 206 to ...

Transdermal drug delivery has made a notable contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. While transdermal delivery systems would appear to provide an attractive solution for local and systemic drug delivery, only a limited number of drugs can be delivered through the outer layer of the skin. The most...

Osteosarcoma is a malignancy of the bone that primarily affects adolescents. Current treatments retain mortality rates, which are higher than average cancer mortality rates for the adolescent age group. We designed a micellar delivery system with the aim to increase drug accumulation in the tumor and potentially reduce side effects associated with chemotherapy. The design features are the use o...

Hydrogels are hydrophilic, three-dimensional networks able to imprison large amounts of water and largely used in pharmaceutical formulations. frequently obtained from hydrophilic polymers, either natural, biohybrid, or synthetic. Owing their peculiar structure, dendrimers can be considered prospective building blocks for hydrogel networks. This review gathers the use different types amphiphili...

This paper reports the fabrication of drug-loaded microspheres by the spray drying method. The microspheres are then compressed by a hydraulic hand press and a die into a disc. The characterization of the microspheres and the effects of different drug loading percentage on the release profile of the drug from the disc are investigated. The effects of different types of polymers used for the fab...

Co-delivery of several drugs has been regarded as an alternative strategy for achieving enhanced therapeutic effect. In this study, a co-delivery system based on the electrospun poly(lactic-co-glycolic acid) (PLGA)/mesoporous silica nanoparticles (MSNs) composite mat was designed for the co-encapsulation and prolonged release of one hydrophilic and one hydrophobic drug simultaneously. MSNs were...

Abstract Hydrophilic polymers have been recognized for enhancing the physico‐chemical and biological properties of synthetic polyesters in field cancer treatment tissue engineering. In this article, anticancer drug, 5‐fluorouracil loaded membranes were prepared with polycaprolactone blended chitosan, hydroxypropyl methyl cellulose polyethylene glycol to study drug release ability breast alongsi...

The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the pre...