نتایج جستجو برای: hydrazone

تعداد نتایج: 2025  

Journal: :Biomacromolecules 2010
Xiuli Hu Shi Liu Yubin Huang Xuesi Chen Xiabin Jing

Doxorubicin (Dox) was conjugated onto a biodegradable block copolymer methoxy-poly(ethylene glycol)-block-poly(lactide-co-2,2-dihydroxymethylpropylene carbonate (mPEG-b-P(LA-co-DHP)) via a carbamate linkage and an acid-labile hydrazone linkage, respectively. Mutifunctional mixed micelles consisting of Dox-containing copolymer mPEG-b-P(LA-co-DHP/Dox) and folic acid-containing copolymer mPEG-b-P(...

Journal: :Journal für Praktische Chemie 1893

Journal: :Physical Sciences Reviews 2021

Journal: :Chemical communications 2011
Sophie R Beeren Michael Pittelkow Jeremy K M Sanders

Thermodynamic control over kinetically-trapped mixtures of hydrazone-based macrocycles is achieved by addition of an aromatic monohydrazide to generate dynamic combinatorial libraries (DCLs) of linear and macrocyclic oligomers.

2011
Yan-Juan Gu Jinping Cheng Jiefu Jin Shuk Han Cheng Wing-Tak Wong

Single-walled carbon nanotubes (SWNTs) have been identified as an efficient drug carrier. Here a controlled drug-delivery system based on SWNTs coated with doxorubicin (DOX) through hydrazone bonds was developed, because the hydrazone bond is more sensitive to tumor microenvironments than other covalent linkers. The SWNTs were firstly stabilized with polyethylene glycol (H(2)N-PEG-NH(2)). Hydra...

Journal: :Journal of bacteriology 2012
Kosuke Taniyama Hideomi Itoh Atsushi Takuwa Yasuyuki Sasaki Shunsuke Yajima Masanori Toyofuku Nobuhiko Nomura Naoki Takaya

Hydrazones are natural and synthetic compounds containing a C=N-N moiety. Here we found that the opportunistic pathogen Pseudomonas aeruginosa PAO1 produced NAD(+)- or NADP(+)-dependent hydrazone dehydrogenase (HDH), which converts hydrazones to the corresponding hydrazides and acids rather than to the simple hydrolytic product aldehydes. Gene cloning indicated that the HDH is part of the group...

2010
Steven Sai Hang Ho K. F. Ho W. D. Liu S. C. Lee W. T. Dai J. J. Cao

Measurements of aldehydes and ketones are typically conducted by derivatization using sorbent cartridges coated with 2,4-dinitrophenylhydrazine (DNPH). The collected samples are eluted with acetonitrile and analyzed by high-pressure liquid chromatography coupled with an ultra-violet detector (HPLC/UV). This paper intends to examine artifacts about its suitability in identification of unsaturate...

Journal: :Molecules 2017
Elena Pahonțu Diana-Carolina Ilieș Sergiu Shova Camelia Oprean Virgil Păunescu Octavian Tudorel Olaru Flavian Ștefan Rădulescu Aurelian Gulea Tudor Roșu Doina Drăgănescu

Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H-NMR and 13C-NMR (hydrogen and carbon nuclear m...

Journal: :Molecules 2007
Sevim Rollas S Güniz Küçükgüzel

There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Th...

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