BACKGROUND Apolipoprotein E (apoE)/endothelial nitric oxide synthase (eNOS) double knockout (DKO) mice demonstrate accelerated atherosclerosis and develop abdominal aortic aneurysms and aortic dissection, suggesting a role for eNOS in suppressing atherogenesis. To test whether accelerated atherosclerosis and aortic aneurysms were due to hypertension, we administered hydralazine to male apoE/eNO...

BACKGROUND Down regulation of genes coding for nucleoside transporters and drug metabolism responsible for uptake and metabolic activation of the nucleoside gemcitabine is related with acquired tumor resistance against this agent. Hydralazine has been shown to reverse doxorubicin resistance in a model of breast cancer. Here we wanted to investigate whether epigenetic mechanisms are responsible ...

We report a case of hydralazine-induced ANCA-associated glomerulonephritis with pulmonary hemorrhage. A 62-year-old Hispanic man with hypertension, who was being treated with hydralazine 100 mg three times a day for four and half years, presented to the hospital with severe anemia. He had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. CT scan of the c...

The goal of the current study was to determine whether treatment of hypertension reduces cerebral infarction after occlusion of the middle cerebral artery in stroke-prone spontaneously hypertensive rats (SHRSPs). Three-month-old SHRSPs received untreated drinking water or drinking water containing cilazapril, an angiotensin converting enzyme inhibitor, or hydralazine and hydrochlorothiazide. Af...

1. Hydralazine relaxes the rat tail artery by a direct action on vascular smooth muscle cells, which appears to be modulated by the action of sympathetic nerve terminals. 2. There is a gradient of response to hydralazine in arteries from normotensive Wistar rats, the proximal segments being poorly responsive. This gradient disappears after denervation with 6-hydroxydopamine in vitro. 3. Exogeno...

In 14 patients with chronic heart failure, changes in coronary hemodynamics, myocardial metabolism and left ventricular function were evaluated after administration of captopril, prazosin and hydralazine. Eleven patients received captopril in incremental doses (6.25-150 mg) until the arterial pressure decreased by 10 mm Hg; 11 patients received prazosin (5 mg) and 10 patients received hydralazi...

To determine the hemodynamic effects of afterload reduction at rest and during upright exercise in patients with coronary artery disease and left ventricular dysfunction, 12 patients were studied before and after taking 50-75 mg of oral hydralazine every 6 hours for 48 hours. Oxygen consumption and heart rate were unchanged from control both at rest and during two work loads on a bicycle ergome...

The clinical use of hydralazine in combination with organic nitrates has resulted in a beneficial effect on survival, cardiac function, and exercise tolerance. More recently, hydralazine has been shown to prevent development of nitrate tolerance and early attenuation of nitrate-mediated hemodynamic effects in both experimental animals as well as patients with severe heart failure due to depress...

We have previously shown that acrolein, a lipid peroxidation byproduct, is significantly increased following spinal cord injury in vivo, and that exposure to neuronal cells results in oxidative stress, mitochondrial dysfunction, increased membrane permeability, impaired axonal conductivity, and eventually cell death. Acrolein thus may be a key player in the pathogenesis of spinal cord injury, w...

Basilar Arterial Flow Changes Elicited by Hydralazine Hydrochloride, Isoxsuprine Hydrochloride and Nylidrin Hydrochloride • The influence of infusion of hydralazine, isoxsuprine or nylidrin on blood flow in the basilar artery and on systemic blood pressure was investigated in anesthetized dogs. The drugs were administered individually in 1-mg and 2-mg doses and in various combinations of 1 mg e...