Complete hydatidiform moles (CHMs) are tissues carrying duplicated haploid genomes derived from single sperms, and detecting copy number variations (CNVs) in CHMs is assumed to be sensitive and straightforward methods. We genotyped 108 CHM genomes using Affymetrix SNP 6.0 (GEO#: GSE18642) and Illumina 1 M-duo (GEO#: GSE54948). After quality control, we obtained 84 definitive haplotype consistin...

Many problems of clinical as well as of pathological interest gather round the group of tumours of which the hydatidiform mole and the chorion epithelioma are the commonest examples. Amongst the chief points of clinical interest are: (i) The question of the frequency of such growths. Williamson states that moles occur in the proportion of one in 2400 pregnancies. On the other hand, Meyer1 claim...

A clinicohistological study of acute atherosis in molar pregnancy was undertaken. Maternal decidual vessels in currettage samples of 38 histologically confirmed complete hydatidiform moles were examined histologically for acute atherosis, recognised as fibrinoid necrosis of the smooth muscle wall with a perivascular mononuclear cell infiltrate, with or without lipophages. Acute atherosis was de...

The methylation status of genes in hydatidiform mole and choriocarcinoma and its significance is relatively unexplored. We investigated the methylation status of the promoter regions of six genes, p16, HIC-1, TIMP3, GSTP1, death-associated protein kinase (DAPK), and E-cadherin in 54 hydatidiform moles, five choriocarcinomas, and 10 first trimester placenta by methylation-specific polymerase cha...

Copyright: © 2012 Hui P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In recent months, two specialty pathology journals chose article images of molecular diagnosis of hydatidiform mole as the journal front...

Vaginal bleeding 187 (81.3) 297 (97.1) 0.001 Anemia 32 (13.9) 165 (53.9) 0.001 Uterine size larger than date 78 (33.9) 156 (51.0) 0.001 Hyperemesis 69 (30.0) 80 (26.1) 0.847 Gestational trophoblastic disease (GTD) comprises a spectrum of tumors with benign or malignant potential, including hydatidiform mole, invasivemole, choriocarcinoma, and placental site trophoblastic tumor. Hydatidiform mol...

OBJECTIVES The aim of this study was to determine whether the concentration of disintegrin and metalloprotease protein12 (ADAM12) in first trimester maternal serum can be used as a marker for first-trimester complete spontaneous abortions, missed abortions, ectopic pregnancies and hydatidiform moles. METHODS The maternal serum concentrations of ADAM12 were measured in the range of 5-9+6 weeks...

Previous studies indicate that epigenetic modifications play an important role in transcriptional regulation and contribute to the pathogenesis of gestational trophoblastic disease, including complete hydatidiform moles (CHMs). However, the underlying mechanisms and the critical genes have not been clearly identified. In the present study, we developed a novel technique, NotI subtraction and me...

BACKGROUND Hydatidiform mole is an important obstetric problem which can result in harmful and serious outcomes. In this study, an attempt was made to determine the proportion of hydatidiform mole in prenatal clinics of Iran University of Medical Sciences (IUMS) to find the precise frequency of this disease. METHODS Between January 2012 and January 2013, all women who immediately after positi...