injection of synthetic fillers for soft tissue augmentation is increasing over the last decade. one of the most common materials used is hyaluronic acid (ha) that is safe and temporary filler for soft tissue augmentation. we present a case of 54-year-old female who experienced vascular occlusion and nasal alar necrosis following ha injection to the nasolabial folds. she suffered from pain, necr...

Injectable dermal fillers, which are used for various plastic surgery purposes, experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material fillers their high-water retention, biodegradability, and biocompatibility. However, application is limited by shortcomings durability persistence caused rap...

Deep cutaneous lesions such as burns, traumas or ulcers are all conditions characterized by a massive loss of dermis, bringing several important consequences. For the treatment of these conditions, the evolution of material science has made available new dressings based on natural and synthetic polymers. Hyaluronic acid (HA) is involved in many steps of the wound healing process, such as inflam...

Schistosomiasis mansoni is a chronic liver disease that is endemic in rural areas of Egypt. Some patients may acquire infection and develop minimal complications, while others may develop severe complications and progress to portal hypertension and cirrhosis, especially if coinfected with viral hepatitis [1,2]. Egypt has the highest worldwide prevalence for the concomitant infection of schistos...

OBJECTIVE Viscosupplementation with hyaluronic acid (HA) or its derivatives for the symptomatic relief of osteoarthritis (OA) of the hip joint has never been studied in placebo-controlled, double-blinded trials and conflicting results have been obtained from the published open trials. The aim of this study was to review the literature on viscosupplementation as a symptomatic treatment of hip OA...

A 3D tumor microenvironment model is presented, combining hyaluronic acid (HA) and alginate. The can be used to mimic the bioactivity of HA in gastric cancer, as well crosstalk between cancer cells mesenchymal stem cells.

The purposes of this study are to characterize the binding of hyaluronic acid (HA) to mouse T lymphoma cells, to measure changes in intracellular Ca2+ after HA binding, to elucidate the interaction between the HA receptor, GP85(CD44), and ankyrin in the membrane skeleton, and finally to correlate these events with HA receptor patching/capping and cell adhesion to HA. First, we established an in...

The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weight hyaluronic acid (HA) oral tablets or placebo for three months. Vaginal biopsies were t...

Despite being a complex degenerative joint disease, studies on osteoarthritis (OA) suggest that its progression can be reduced by the use of hyaluronic acid (HA) or mesenchymal stem cells (MSC). The present study thus aims to examine the effects of MSC, HA and the combination of HA-MSC in treating OA in rat model. The histological observations using O'Driscoll score indicate that it is the use ...

Purpose Hyaluronic Acid (HA) has a role as “physiologic selector” for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme. Methods We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group)...