نتایج جستجو برای: human spermatogonial stem cell

تعداد نتایج: 3025141  

2014
Mohammadreza Gholami Ghasem Saki Masoud Hemadi Ali Khodadadi Javad Mohammadi-asl

OBJECTIVE(S) Transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. Melatonin is secreted from the pineal gland and some organs such as testes. According to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantatio...

2013
Ten-Tsao Wong Paul Collodi

Zebrafish spermatogonial cell cultures were established from Tg(piwil1:neo);Tg(piwil1:DsRed) transgenic fish using a zebrafish ovarian feeder cell line (OFC3) that was engineered to express zebrafish Lif, Fgf2 and Gdnf. Primary cultures, initiated from testes, were treated with G418 to eliminate the somatic cells and select for the piwil1:neo expressing spermatogonia. Addition of dorsomorphin, ...

Journal: :Philosophical Transactions of the Royal Society B: Biological Sciences 2010

Journal: :Human reproduction update 2006
Jens Ehmcke Joachim Wistuba Stefan Schlatt

This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the...

Journal: :international journal of reproductive biomedicine 0
karim nayernia jae ho lee wolfgang engel jessica nolte nadja drusenheimer kristina rathsack

germline and somatic stem cells are distinct types of stem cells that are dedicated to reproduction and somatic tissue regeneration, respectively. germline stem cells (gscs), which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. we developed a strategy for the establishment of germline st...

Journal: :cell journal 0
morteza koruji hossein azizi abdolhossein shahverdi hossein baharvand

spermatogonial stem cells (sscs) are in the beginning of a complex process in which they transmit genetic information from generation to generation. any failure in this process can result in infertility. it has been suggested that transplantation of spermatogonial stem cells, following their maintenance and culturing, may restore fertility in some infertile patients. because fertility restorati...

Journal: :Human reproduction 2003
M Kanatsu-Shinohara N Ogonuki K Inoue A Ogura S Toyokuni T Shinohara

BACKGROUND The development of a spermatogonial transplantation technique has provided new possibilities for the treatment of male infertility. Previous studies have shown that spermatogonial stem cells could reinitiate spermatogenesis after cryopreservation and reintroduction into the seminiferous tubules of infertile recipient males, and this raised the possibility of banking frozen stem cells...

2013
Neda Eslahi Mahmoud Reza Hadjighassem Mohammad Taghi Joghataei Tooba Mirzapour Mehrdad Bakhtiyari Malak Shakeri Vahid Pirhajati Peymaneh Shirinbayan Morteza Koruji

INTRODUCTION A 3D-nanofiber scaffold acts in a similar way to the extracellular matrix (ECM)/basement membrane that enhances the proliferation and self-renewal of stem cells. The goal of the present study was to investigate the effects of a poly L-lactic acid (PLLA) nanofiber scaffold on frozen-thawed neonate mouse spermatogonial stem cells (SSCs) and testis tissues. METHODS The isolated sper...

Ghorbanian, Mohammad taghi, Mahal Dashtian, Maryam, Makoolati, Zohreh, Naghdi, Majid,

Spermatogenesis is a highly complex and regulated process in which germ stem cells differentiate into spermatozoa. These stem cells, called spermatogonial stem cells (SSCs), are in the base of seminiferous tubules and have the ability of self-renewal and differentiation into functional germ cells. Due to this ability, SSCs can restore spermatogenesis after testicular damage caused by cytotoxic ...

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