نتایج جستجو برای: human interferon γ
تعداد نتایج: 1748125 فیلتر نتایج به سال:
UNLABELLED While cervical cancer incidence and mortality rates have declined in the United States, this cancer represents a worldwide threat. Human papilloma viral infection causes cervical neoplasia (CIN). 3,3'-Diindolylmethane (DIM) prevents or inhibits the progression from cervical dysplasia to cancer. The aim of this study is to determine the most effective dose of DIM given continuously in...
Autoimmune thyroid diseases (ATDs) represent the most frequent forms of the organ-specific autoimmune thyroid disorders that result from interaction between genetic and environmental factors. Selenium has been shown to exert a beneficial effect on the autoimmune thyroiditis. In spite of therapeutical effect of selenium on autoimmunity, the mechanism of its action has not been revealed. Objectiv...
We developed an interferon-γ release assay (IGRA) specific for Asian elephants (Elephas maximus). Whole blood collected from forty captive Asian elephants was stimulated with three different mitogens i.e., phytohemagglutinin (PHA), pokweed mitogen (PWM) and phorbol myristate aceteate/ionomycin (PMA/I). A sandwich ELISA that was able to recognize the recombinant elephant interferon-γ (rEIFN-γ) a...
Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group ...
Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successf...
BACKGROUND Interferon-γ (IFN-γ) plays an important role in the proceedings of vitiligo through recruiting lymphocytes to the lesional skin. However, the potential effects of IFN-γ on skin melanocytes and the subsequent contribution to the vitiligo pathogenesis are still unclear. OBJECTIVE To investigate the effects of IFN-γ on viability and cellular functions of melanocytes. METHODS Primary...
normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 objectives: there is an association between viral infection and development of diabetes mellitus. this study aimed to investigate the role of rubella virus, cytomegalovirus and coxsackievirus in patients with type 1 (t1d)and type 2 (t2d) diabetes mellitus in respect to the glycemic control and immune response presented by ...
1998, 18(9):5166. Mol. Cell. Biol. Stephen B. Baylin and Francis W. Ruscetti Turcoski-Corrales, Dennis D. Taub, Cari L. Petrow, Jean-Pierre J. Issa, Paula M. Pitha, Susan Judy A. Mikovits, Howard A. Young, Paula Vertino, Production γ Downregulation of IFN) Promoter and Subsequent γ Methylation of the Gamma Interferon (IFNMethyltransferase, Resulting in De Novo Virus Type 1 Upregulates DNA Infec...
Type I interferon (IFN) signaling engenders an antiviral state that likely plays an important role in constraining HIV-1 transmission and contributes to defining subsequent AIDS pathogenesis. Type II IFN (IFN-γ) also induces an antiviral state but is often primarily considered to be an immunomodulatory cytokine. We report that IFN-γ stimulation can induce an antiviral state that can be both dis...
The IFNs are a family of secreted glycoproteins that play roles in regulation of antiviral, antiproliferative, and immunomodulatory responses in vertebrate cells. Two types of IFNs have been described, the type I IFNs (α, β, ω, and τ) that are produced by leukocytes and fibroblasts, and the type II IFN (γ) that is produced by T-lymphocytes and natural killer cells in response to infections by v...
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