The role of vascular coagulation receptors, particularly modest changes in the levels of these proteins in terms of controlling downstream coagulation factor activation, remains largely unknown. The study reported by Ireland and colleagues in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology1 demonstrates that a moderately common dimorphism in the endothelial cell protein C recep...

One pathway of blood coagulation, the extrinsic system, is initiated by a specific interaction between tissue factor, which is a membrane lipoprotein, and factor VII, one of the plasma coagulation factors. Factor VII was prepared from bovine plasma by adsorption onto and elution from BaSO(4). The eluate was chromatographed on DEAE-Sephadex and purified by preparative disc-gel electrophoresis. F...

By S00NA S. SETNA .-5’NI) S. J. ALTMAN I T IS \VELL KNO\VX that deficiencies of prothrombimi and proconvertin can I)e the cause of serious bleedimig.’’ In addition to recognized causes of these deficiencies, su(’h as inadequate imitake, aI)sorption or utilization of vitamin K, cases of unrecognized cause may be emicountered.6 To date, an acquired idiopathic deficiency of these two sul)stamices ...

A family with a peculiar defect of factor VII is described. The propositi, a brother and sister, were born of a nonconsanguineous marriage and presented a mild to moderate bleeding tendency since childhood (epistaxis, excessive bleeding after tooth extraction). The coagulation pattern was characterized by a mildly prolonged prothrombin time, normal partial thromboplastin time, and normal Stypve...

Hematol Transfus Int J 2017, 4(2): 00078 those using the anti-coagulant agent, warfarin [4,5]. One case of a patient undergoing coronary artery bypass grafting was noted among 7cases of surgery-associated acquired hemophilia [2]. A 66-year-old man underwent aortic valve replacement for severe aortic valve stenosis. After surgery, he was administered warfarin (2mg/day) for anticoagulation and th...

We have previously shown that human liver myofibroblasts promote in vitro invasion of human hepatocellular carcinoma (HCC) cells through a hepatocyte growth factor (HGF)/urokinase/plasmin-dependent mechanism. In this study, we demonstrate that myofibroblasts synthesize the serine proteinase inhibitor tissue factor pathway inhibitor-2 (TFPI-2). Despite the fact that recombinant TFPI-2 readily in...

Replacement therapy for hemophilia B (factor IX deficiency) using prothrombin complex concentrate (PCC) has been associated with serious complications of thromboembolic events and transmission of viral infections. Monoclonal antibody-purified factor IX (Mononine) provides a highly purified factor IX concentrate, while eliminating other vitamin K-dependent factors (II, VII, and X). Mononine was ...

REFERENCES 1. Monroe DM, Hoffman M, Oliver JA, et al. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99:542-547. 2. Hedner U, Kisiel W. Use of human factor VIIa in the treatment of two hemophilia A patients with high-titer inhibitors. J Clin Invest. 1983;71:1836-1841. 3. Bom VJ, Bertina RM. The contributions of Ca2 , phospholipids and tissue-fact...

INTRODUCTION Invasive pulmonary aspergillosis (IA) is the most frequent invasive fungal infection in patients with hematological malignancies. Massive hemoptysis (MH) with blood loss more than 300-600 ml in 24 hours is a rare (5-10% of IA patients) but frequently fatal complication. Standard treatment of MH, such as oxygenation, a semi-sitting position with the bleeding site down, bronchoscopic...