It has been claimed that proteins with more interacting partners (hubs) are structurally more disordered and have a slow evolutionary rate. Here, in this paper we analyzed the evolutionary rate and structural disorderness of human hub and non-hub proteins present/absent in protein complexes. We observed that both non-hub and hub proteins present in protein complexes, are characterized by high s...

At the apical tip of Drosophila testis, there is a stem cell niche known as the proliferation center, where the stem cells are maintained by hub cell cluster for the regulation of differentiation and proliferation. Germline stem cells go through mitosis four times from one primary spermatogonial cell to the 16-cell stage before the maturation. The cells derived from the same germline stem cell ...

centralizing and using proper transportation facilities cut down costs and traffic. hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. a distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

this paper presents the fatigue life behavior of hub using random vibration based on road roughness. the main objectives of this study are to predict the fatigue life and to identify the critical location for evaluating fatigue damage. asphalt road surface profiles obtained in favorable circumstances by topography cameras and in according road classification iso 2631-1estimate road roughness su...

In this paper, we consider the design of large-scale multiple allocation hub-and-spoke transportation networks in a competitive environment. We adopt a generic hub arc location model that locates arcs with discounted transport costs connecting pairs of hub facilities. Two firms compete for customers in a Stackelberg framework where the leader firm locates hub arcs to maximize its revenue, given...

This study presents an optimal framework for the operation of integrated energy systems using demand response programs. The main goal of integrated energy systems is to optimally supply various demands using different energy carriers such as electricity, heating, and cooling. Considering the power market price, this work investigates the effects of multiple energy storage devices and demand res...

The hub location–allocation problem under uncertainty is a real-world task arising in the areas such as public and freight transportation and telecommunication systems. In many applications, the demand is considered as inexact because of the forecasting inaccuracies or human’s unpredictability. This study addresses the robust uncapacitated multiple allocation hub location problem with a set of ...