Reproducible induction of the enzyme tyrosine aminotransferase by dibutyryl cAMP (Bt2cAMP) in a line of HTC hepatoma cells in suspension culture requires that the cells be preinduced with dexamethasone, a synthetic glucocorticoid which itself induces tyrosine aminotransferase. Concentrations of dexamethasone that do not induce tyrosine aminotransferase fail to support Bt2cAMP induction, removal...

HTC rat hepatoma cells were transfected with human insulin receptor cDNA to a level of 40,000 receptors/cell. In these cells, as well as in nontransfected cells, insulin stimulated the uptake of alpha-aminoisobutyric acid. Two monoclonal antibodies directed against the human insulin receptor alpha subunit, like insulin, stimulated amino acid uptake in transfected HTC cells, but not in nontransf...

Checkpointing is a fault-tolerance mechanism commonly used in High Throughput Computing (HTC) environments to allow the execution of long-running computational tasks on compute resources subject to hardware and software failures and interruptions from resource owners. With increasing scrutiny of the energy consumption of IT infrastructures, it is important to understand the impact of checkpoint...

OBJECTIVE To investigate whether community engagement (participation in grassroots organizations) contributed to increases in HIV testing in Zimbabwe. METHODS Prospective data on membership of local community organizations (e.g. women's groups and burial societies) and uptake of HIV testing and counselling (HTC) and prevention-of-mother-to-child transmission (PMTCT) services were collected fr...

It is well known that athletes and other individuals who have suffered painful injuries are at increased risk for all reward deficiency syndrome (RDS) behaviors, including substance use disorder (SUD). Comparing patient demographics and relapse rates in chemical dependence programs is pertinent because demographics may affect outcomes. Increased risk for relapse and lower academic achievement w...

To build systems that can deal with the individual differences of users, we need to represent a model of the user. Such a user model can support interpretation of user actions and drive the system's actions. This paper takes considerable care in defining the various notions of 'user model'. From this, we characterise the promise of user modelling in terms of the individualisation it offers. The...

The basal level and hormone-affectedaminoacidtrans portof rat hepatocytesand rat hepatomacell lines H4-bI E-C3 (H35), HTC, McA-RH8994 (8994), and McA-RH7777 (7777) in culture were examined by investigating the amount of a-[1-14C]-aminoisobutyricacid (AIB) trans ported in 4 mm and up to 4 hr at 37°. The substances testedwere insulin,dexamethasone(DEX),glucagon,and dibutyryl cyclic adenosine 3' ...

Investigating molecular mechanisms underlying human taste sensation requires functionally dedicated and at the same time proliferating human taste cells. Here, we isolated viable human fungiform taste papillae cells from biopsy samples, adenovirally transduced proliferation promoting genes, and obtained stably proliferating cell lines. Analysis of gene expression of 1 human taste cell line term...

Glucocorticoids affect the composition and function of the plasma membrane in a variety of cell types.' Incubation of HTC cells, an established line of rat hepatoma cells in tissue culture, with the synthetic glucocorticoid dexamethasone (DEX) alters several membrane properties characteristic of transformed cells, without affecting the growth rate of these cells. Dexamethasone rapidly and rever...

High throughput computing (HTC) is of great importance in grid computing environments. HTC is aimed at minimizing the total makespan of all of the tasks submitted to the grid environment in long execution of the system. To achieve HTC in grids, suitable task scheduling algorithms should be applied to dispatch the submitted tasks to the computational resources appropriately. In this paper, a new...