A hematoporphyrin derivative (abbreviated in the literature as "HPD") has been used successfully for phototherapy of tumors in the clinic. The chemical nature of HPD, a complex mixture of porphyrins, is not fully understood. This study was designed to provide an explanation for the superior tumorlocalizing ability of HPD. Chromatographie behavior, hydrophobicity, transport, binding, and photose...

New developments in HPD design are presented, triggered by applications in high energy physics and astrophysics. The presented HPD designs are based on three innovations. (i) In order to achieve the highest possible surface coverage in a RICH detector, we introduced a photoelectron focussing method which is efficient to the periphery of the photocathode. (ii) To prevent positive ion feedback in...

The photosensitizing activity of hematoporphyrin derivative (HPD) was investigated by studying selected enzymes localized to mitochondria and cytosol of R3230AC mammary adenocarcinomas. Experiments in vitro demonstrated that mitochondrial succinate dehydrogenase was inhibited in a drug dose- and light exposure time-related manner; at 7.0 micrograms of HPD per ml or higher, enzyme activity was i...

Fatigue in a material occurs when it is subjected to fluctuating stress and strain, which usually results failure due the accumulated damage. In statistics, asymmetric distribution, commonly used for describing fatigue life of materials, Birnbaum–Saunders (BS) distribution. This distribution can be transform normal symmetrical. Furthermore, variance examine dispersion data. However, comparing v...

Twenty-eight porphyrins were evaluated for tumor localization as delineated by fluorescence using a transplantable KHJJ mammary car cinoma in BALB/c mice as the tumor model. Five of the 28 porphyrins were found to localize and of these, one, i.e., uroporphyrin I (UROP I), showed a higher tumorskin ratio than any of the others; moreover, as no measurable DROP I was present in the gut, the tumori...

The objective of this study was to determine the effects of topical 0.5% tropicamide, 1% atropine sulphate and 10% phenylephrine hydrochloride ophthalmic solutions on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the dog during the first hour after treatment. Forty clinically and ophthalmologically normal canine patients (between the ages of 2 and 6 years) of varying breed a...

Hematoporphyrin derivative (HpD) is a systemically administered photosensitizing agent that may be of value in the treatment of solid tumors. When corneal endothelial cells were perfused in the specular microscope with HpD and exposed to a 25-W incandescent light at 5 cm (5.5 mW/cm2) there was anatomic disruption of corneal endothelial cells and swelling of the corneal stroma. Perfusion with 0....

Energy-restricted high-protein diets (HPDs) have shown favorable results for body weight (BW) management, yet studies differ in their outcomes depending on the dietary protein content. Our objective was to determine the effects of dietary protein content on BW loss-related variables during a 6-mo energy restriction with the use of diets containing protein at the level of requirement [normal-pro...

A decade ago, a new mite-transmitted disease was described on wheat (Triticum aesativum) and maize (Zea mays) that due to its geographical location was referred to as High Plains Disease (HPD). To determine the etiology, we established colonies of HPD pathogen-transmitting eriophyid wheat curl mites (Aceria tosichella) on wheat plants for maintenance of a continuous source of infected material....

Energy-restricted high-protein diets (HPDs) have shown favorable results for body weight (BW) management, yet studies differ in their outcomes depending on the dietary protein content. Our objective was to determine the effects of dietary protein content on BW loss-related variables during a 6-mo energy restriction with the use of diets containing protein at the level of requirement [normal-pro...