نتایج جستجو برای: hotspots

تعداد نتایج: 8181  

Journal: :I. J. Comput. Appl. 2009
Dana Steil Allen S. Parrish

The purpose of this GIS-based hotspot identification taxonomy is to bring together strategies for planning and evaluation of selective traffic enforcement programs (STEPs). The HIT model is specifically designed for enforcement programs that focus on events and countermeasures that can be spatially and temporally described. The HIT model encompasses four core activities that are tightly integra...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Kyle S Smith Kent C Berridge

Mu-opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other...

2013
James West Stephan Beck Xiangdong Wang Andrew E. Teschendorff

Epigenetic changes have been associated with ageing and cancer. Identifying and interpreting epigenetic changes associated with such phenotypes may benefit from integration with protein interactome models. We here develop and validate a novel integrative epigenome-interactome approach to identify differential methylation interactome hotspots associated with a phenotype of interest. We apply the...

Journal: :Science 2008
Graham Coop Xiaoquan Wen Carole Ober Jonathan K Pritchard Molly Przeworski

Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To examine variation in fine-scale recombination patterns among individuals, we used dense, genome-wide single-nucleo...

2007
DAVID C. EVERS YOUNG-JI HAN CHARLES T. DRISCOLL NEIL C. KAMMAN M. WING GOODALE KATHLEEN FALLON LAMBERT THOMAS M. HOLSEN CELIA Y. CHEN THOMAS A. CLAIR

Biological mercury (Hg) hotspots were identified in the northeastern United States and southeastern Canada using a data set of biotic Hg concentrations. Eight layers representing three major taxa and more than 7300 observations were used to locate five biological Hg hotspots and nine areas of concern. The yellow perch and common loon were chosen as indicator species for the human and ecological...

2013
Cristina Martín-Castellanos Kyle R. Fowler Gerald R. Smith

Meiosis is a special cell division program that reduces the diploid chromosome set to a haploid set for sexual reproduction. Reductional segregation of homologous chromosomes is helped by physical linkages (crossovers) provided by recombina-tion. A long-standing problem in biology has been to understand how meiotic recom-bination is controlled, since its initiation by DNA double-strand breaks (...

Journal: :Genetics 2015
Xuan Zhu Scott Keeney

Meiotic recombination initiates with DNA double-strand breaks (DSBs) made by Spo11. In Saccharomyces cerevisiae, many DSBs occur in "hotspots" coinciding with nucleosome-depleted gene promoters. Transcription factors (TFs) stimulate DSB formation in some hotspots, but TF roles are complex and variable between locations. Until now, available data for TF effects on global DSB patterns were of low...

2016
Kyuha Choi Carsten Reinhard Heïdi Serra Piotr A Ziolkowski Charles J Underwood Xiaohui Zhao Thomas J Hardcastle Nataliya E Yelina Catherine Griffin Matthew Jackson Christine Mézard Gil McVean Gregory P Copenhaver Ian R Henderson

Meiotic crossover frequency varies extensively along chromosomes and is typically concentrated in hotspots. As recombination increases genetic diversity, hotspots are predicted to occur at immunity genes, where variation may be beneficial. A major component of plant immunity is recognition of pathogen Avirulence (Avr) effectors by resistance (R) genes that encode NBS-LRR domain proteins. Theref...

Journal: :Remote Sensing 2009
Veerachai Tanpipat Kiyoshi Honda Prayoonyong Nuchaiya

To ensure remote sensing MODIS hotspot (also known as active fire products or hotspots) quality and precision in forest fire control and management in Thailand, an increased level of confidence is needed. Accuracy assessment of MODIS hotspots utilizing field survey data validation is described. A quantitative evaluation of MODIS hotspot products has been carried out since the 2007 forest fire s...

2005
Stephan Groß Sabine Lein Sandra Steinbrecher

Beginning with the adoption of the de-facto standard for wireless LAN communications IEEE 802.11 in 1999 we can observe a continuous growth of public wireless LAN hotspots that provide access to the Internet for modern road warriors. Unfortunately, current hotspots still suffer from several security drawbacks. In this paper we analyse how payment schemes used in current hotspot architectures co...

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