The sarcoglycan sub-complex is a protein system which plays key role in sarcolemma stabilization during muscle activity consisting of six glycosylated transmembrane proteins. Integrins play the process cell adhesion, linking extracellular matrix to actin cytoskeleton. Here we have analysed receptor for thyroid hormone, identified on αvβ3-integrin that has an important activation non-genomic act...

Background: Breast cancer (BC) is problem in developed and developing nations linked to a high mortality rate. Objective: In this study, we determined the relationships between osteopontin level, hormonal status, stage, BMI, age BC patients. Materials Methods: cross sectional 178 patients, ages ranged from 28 95 were randomly enrolled. Body mass index estimated. Plasma measured. Results: From t...

Triple-negative breast cancer (TNBC) is considered one of the most aggressive forms with poor survival rates compared to other subtypes. TNBC characterized by absence estrogen receptor alpha, progesterone receptor, and human epidermal growth factor 2, limiting those viable treatment options available patients Furthermore, due particularly high heterogeneity TNBC, conventional treatments such as...

Breast cancers classified by estrogen receptor (ER) and/or progesterone receptor (PR) expression have different clinical, pathologic, and molecular features. We examined existing evidence from the epidemiologic literature as to whether breast cancers stratified by hormone receptor status are also etiologically distinct diseases. Despite limited statistical power and nonstandardized receptor ass...

Thyroid-stimulating hormone alpha and beta subunit genes are negatively regulated by thyroid hormone at the transcriptional level. Transient gene expression studies were used to demonstrate that the erbA beta form of the thyroid hormone receptor mediates negative regulation of the alpha-subunit promoter in a hormone-dependent manner. In JEG-3 choriocarcinoma cells, which are deficient in thyroi...