Background: Lipophosphoglycan 3 (LPG3) is required for the LPG assembly, a well known virulent molecule. In this study, the LPG3 gene of the lizard and mammalian Leishmania species were cloned and sequenced. A three-dimensional structure (3D) for the target sequence was also predicted by comparative (homology) modeling. Materials and Methods: An optimization PCR amplification was performed o...

Higher dimensional automata, i.e. labelled precubical sets, model concurrent systems. We introduce the homology graph of an HDA, which is a directed graph whose nodes are the homology classes of the HDA. We show that the homology graph is invariant under homeomorphic abstraction, i.e. under weak morphisms that are homeomorphisms.

We propose a method, based on persistent homology, to uncover topological properties of a priori unknown covariates of neuron activity. Our input data consist of spike train measurements of a set of neurons of interest, a candidate list of the known stimuli that govern neuron activity, and the corresponding state of the animal throughout the experiment performed. Using a generalized linear mode...

We introduce affine Stanley symmetric functions for the special orthogonal groups, a class of symmetric functions that model the cohomology of the affine Grassmannian, continuing the work of Lam and Lam, Schilling, and Shimozono on the special linear and symplectic groups, respectively. For the odd orthogonal groups, a Hopf-algebra isomorphism is given, identifying (co)homology Schubert classes...

Bacteriorhodopsin (bR) is a light-driven proton pump, which is a membrane protein with seven transmembrane helices and a prosthetic group of retinal. The structure of bR has been determined at high resolution, and the homology modeling of G-protein coupled receptors, which have seven transmembrane helices, is usually carried out based on the structure of bR as the structure template. However, t...

objective: crispr/cas9 technology provides a powerful tool for targeted modification of genomes. in this system, a donor dna harboring two flanking homology arms is mostly used for targeted insertion of long exogenous dna. here, we introduced an alternative design for the donor dna by incorporation of a single short homology arm into a circular plasmid. materials and methods: in this experiment...

A fundamental goal of algebraic geometry is to do for singular varieties whatever we can do for smooth ones. Intersection homology, for example, directly produces groups associated to any variety which have almost all the properties of the usual homology groups of a smooth variety. Minimal model theory suggests the possibility of working more indirectly by relating any singular variety to a var...

This paper presents an algorithm for combining pattern recognition-based exon prediction and database homology search in gene model construction. The goal is to use homologous genes or partial genes existing in the database as reference models while constructing (multiple) gene models from exon candidates predicted by pattern recognition methods. A unified framework for gene modeling is used fo...

The purpose of this paper is to explore the relationship between the cyclic homology and cohomology theories of Connes [9-11], see also Loday and Quillen [20], and "IF equivariant homology and cohomology theories. Here II" is the circle group. The most general results involve the definitions of the cyclic homology of cyclic chain complexes and the notions of cyclic and cocyclic spaces so precis...