نتایج جستجو برای: hla g downregulation
تعداد نتایج: 503600 فیلتر نتایج به سال:
Nonclassical major histocompatibility complex (MHC) class I human leukocyte antigen E (HLA-E) and HLA-G molecules differ from classical ones by specific patterns of transcription, protein expression, and immunotolerant functions. The HLA-G molecule can be expressed as four membrane-bound (HLA-G1 to -G4) and three soluble (HLA-G5 to -G7) proteins upon alternative splicing of its primary transcri...
background: pregnancy is a successful transplantation. the factors evading rejection of the fetus are poorly understood. recently an interest has grown, in hla-g molecules as one of these factors. since these antigens are mainly expressed on the surface of cytotro-phoblasts that are in direct contact with maternal tissues, it has been suggested that these molecules may have a role in induction ...
Curigliano and Criscitiello, et al. [7] have addressed the molecular pathways of HLA-G. There are seven isoforms, four membrane bound (HLA-G1 to HLA-G-4); and three secreted isoforms (s HLA-G; HLA-G5 to HLA-G7). HLA-G5 is the soluble counterpart of HLA-G1; and most information known concerns the HLA-G1 molecule and its soluble counterpart HLA-G5. HLA-G induces tolerance and tumor Immunosuppress...
زمینه و هدف: بارداری، در واقع مانند پیوند عضوی موفق است. عواملی که در عدم دفع جنین مؤثرند هنوز به خوبی شناخته نشدهاند. درصد موفقیت و لانه گزینی جنین حاصل از روشهای کمک باروری نیز ممکن است به همین عوامل وابسته باشد. ملکول hla-g یکی ازانواع ملکول های mhc کلاس یک غیر کلاسیک است که اخیراً در ارتباط با بارداری مورد توجه زیادی قرار گرفته است. در این مطالعه مقدار hla-gمحلول در سرم زنان تحت درمان با روش...
background: research says that diabetes may develop in over 10% of non-diabetic pregnant women. diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. in most cases, diabetic symptoms disappear after delivery. hla-g has an important role bo...
BACKGROUND HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to inhibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace thei...
BACKGROUND The physiological functions of the classical HLA (human leukocyte antigen) molecules, HLA-A, HLA-B and HLA-C, are to present peptides to T cells and to inhibit the activity of natural killer cells. In contrast, the functions of nonclassical HLA-molecules, such as HLA-E, HLA-F and HLA-G, remain to be established. The expression of HLA-G is largely limited to the placental trophoblast,...
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