نتایج جستجو برای: hla class i

تعداد نتایج: 1404625  

Journal: :The Journal of Experimental Medicine 1996
Lisa K. Denzin Craig Hammond Peter Cresswell

Major histocompatibility complex (MHC) class II-positive cell lines which lack HLA-DM expression accumulate class II molecules associated with residual invariant (I) chain fragments (class II-associated invariant chain peptides [CLIP]). In vitro, HLA-DM catalyzes CLIP dissociation from class II-CLIP complexes, promoting binding of antigenic peptides. Here the physical interaction of HLA-DM with...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
J R Grandis D M Falkner M F Melhem W E Gooding S D Drenning P A Morel

The expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary for the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system. Down-regulation of HLA class I gene expression has been implicated in tumorigenesis, including squamous cell carcinoma of the head and neck (SCCHN). Loss of MHC class I antigens may be one mechanism by w...

Journal: :Genomics 1989
J Ragoussis K Bloemer H Pohla G Messer E H Weiss A Ziegler

To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2 haplotype. Results were obtained mainly by field-inversion gel electrophoresis and Southern blotting techniques. The map extends to 4800 kb an...

Journal: :nephro-urology monthly 0
zohreh rostami nephrology and urology research center, baqiyatallah university of medical sciences, tehran, ir iran; nephrology and urology research center, baqiyatallah university of medical sciences, molla sadra ave, vanak sq. tehran, iran. tel: +98-9121544897, fax: +98-2188934125 nasrollah shafighiee nephrology and urology research center, baqiyatallah university of medical sciences, tehran, ir iran mohammad mahdi baghersad nephrology and urology research center, baqiyatallah university of medical sciences, tehran, ir iran behzad einollahi nephrology and urology research center, baqiyatallah university of medical sciences, tehran, ir iran

background the human leukocyte antigen (hla) system is widely used as a strategy in the search for the etiology of renal function impairment. objectives this study was carried out to detect the most common hla alleles’ distribution in kidney transplant in both donors and recipients, and clarify the association between hla alleles and renal dysfunction immediately after transplantation. patients...

Journal: :Current Biology 1998
Veronique M. Braud David S.J. Allan Douglas Wilson Andrew J. McMichael

BACKGROUND The human major histocompatibility complex (MHC) class lb molecule HLA-E is transcribed in most tissues but little is known about its localisation within the cell. We have recently shown that HLA-E binds signal-sequence-derived peptides from human MHC class I molecules in vitro. RESULTS Using a newly characterised antibody recognising HLA-E, we show that HLA-E is expressed at the c...

2014
Hiro Sato Yoshiyuki Suzuki Munenori Ide Toshihide Katoh Shin-ei Noda Ken Ando Takahiro Oike Yuya Yoshimoto Noriyuki Okonogi Kousaku Mimura Takayuki Asao Hiroyuki Kuwano Takashi Nakano Torbjörn Ramqvist

OBJECTIVE Enhancing immunologic responses, including human leukocyte antigen (HLA) class I expression on tumor cells and recognition and elimination of tumor cells by tumor-specific cytotoxic T lymphocyte (CTL), is considered a novel concept of radiotherapy. The present study examined patients who underwent preoperative hyperthermo-chemoradiotherapy (HCRT) for locally advanced rectal cancer to ...

Journal: :Molecular biology and evolution 1995
A L Hughes

The HLA (human major histocompatibility complex, or MHC) region includes three types of class I MHC genes: (1) class Ia loci (HLA-A, -B, and -C), which are highly expressed and polymorphic; (2) class Ib loci, which have much reduced expression and polymorphism; and (3) unexpressed class I pseudogenes. Phylogenetic analysis suggests that both class Ib loci and class I pseudogenes arose by duplic...

2010
Xin Huang Anke van den Berg Zifen Gao Lydia Visser Ilja Nolte Hans Vos Bouke Hepkema Wierd Kooistra Sibrand Poppema Arjan Diepstra

BACKGROUND In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated. METHODOLOGY/PRINCIPAL FINDINGS We randomly selected 145 cHL pati...

2013
Yuxuan Liu Anke van den Berg Rianne Veenstra Bea Rutgers Ilja Nolte Gustaaf van Imhoff Lydia Visser Arjan Diepstra

Tumor cells of classical Hodgkin lymphoma (cHL) are characterized by a general loss of B cell phenotype, whereas antigen presenting properties are commonly retained. HLA class I is expressed in most EBV+ cHL cases, with an even enhanced expression in a proportion of the cases. Promyelocytic leukemia protein (PML) and special AT-rich region binding protein 1 (SATB1) are two global chromatin orga...

Journal: :Journal of immunology 2010
Esther M de Kruijf Anita Sajet Johanna G H van Nes Russ Natanov Hein Putter Vincent T H B M Smit Gerrit Jan Liefers Peter J van den Elsen Cornelis J H van de Velde Peter J K Kuppen

Nonclassical HLAs, HLA-E and HLA-G, are known to affect clinical outcome in various tumor types. We examined the clinical impact of HLA-E and HLA-G expression in early breast cancer patients, and related the results to tumor expression of classical HLA class I. Our study population (n = 677) consisted of all early breast cancer patients primarily treated with surgery in our center between 1985 ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید