BACKGROUND Studies have shown that the absence of bile in the gut lumen, either by bile duct ligation or bile diversion, induces mucosal injury. However, the mechanism remains elusive. In this study, the role of bile pigments in gut barrier function was investigated in a rat model of bile duct ligation. METHODS Male Sprague Dawley (SD) rats were used in this study. After ligation of bile duct...

OBJECTIVE To describe intracochlear insertion trauma caused by three perimodiolar cochlear implant electrodes. STUDY DESIGN Descriptive histological study of 15 human cadaver temporal bones. METHODS Fifteen cadaver temporal bones underwent surface preparation and were implanted with one of the following perimodiolar electrode arrays: Combi 40+PM (MedEl Corporation), HiFocus II (Advanced Bio...

To evaluate the significance of the renal resistive index (RI) as a noninvasive marker of renal histological damage and a prognostic indicator, we examined RI by Doppler ultrasonography in 202 chronic kidney disease (CKD) patients who underwent renal biopsy. RI increased as the CKD stage progressed and correlated with age, systolic blood pressure, estimated glomerular filtration rate (eGFR), an...

Strength deficits associated with eccentric contraction-induced muscle injury stem, in part, from excitation-contraction uncoupling. FKBP12 is a 12-kDa binding protein known to bind to the skeletal muscle sarcoplasmic reticulum Ca2+ release channel [ryanodine receptor (RyR1)] and plays an important role in excitation-contraction coupling. To assess the effects of FKBP12 deficiency on muscle inj...

The article presents the results of algorithmic testing methods digital histologicalstudy age damage to brain, liver and kidney tissues based on polarization reconstruction maps linear birefringence protein fi brillar networks; determining relationships between temporal change in magnitude statistical moments 1st – 4th orders, which characterize distributions degree crystallization histological...

This study was conducted to evaluate the tissue of liver, gills and kidney Rutillus caspicus exposed to concentrations of 50, 100, 150 mg of Methyl tert-butyl ether, for 7, 14, 21 days. Average water temperature of 19±1 °C, water oxygen of 7.6 ± 0.2 mg/l and zero salinity were measured. A total of 156 fishes were studied in this experiment. In the first, second and third week of the test, three...

The underlying mechanisms leading to deep tissue injury after sustained compressive loading are not well understood. It is hypothesized that initial damage to muscle fibers is induced mechanically by local excessive deformation. Therefore, in this study, an animal model was used to study early damage after compressive loading to elucidate on the damage mechanisms leading to deep pressure ulcers...

The dissociation between magnetic resonance imaging (MRI) and permanent disability in multiple sclerosis (MS), termed the clinicoradiological paradox, can primarily be attributed to the lack of specificity of conventional, relaxivity-based MRI measurements in detecting axonal damage, the primary pathological correlate of long-term impairment in MS. Diffusion tensor imaging (DTI) has shown promi...

Xian, C. J., G. S. Howarth, C. E. Mardell, J. C. Cool, M. Familari, L. C. Read, and A. S. Giraud. Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G785–G795, 1999.—Trefoil factor TFF3 has been implicated in intestinal protection and repair. This study investigated the spatiotemporal r...

Background: The alkylating agent busulfan adversely affects spermatogenesis in mammals and Impairment of spermatogenesis has been identified as an inevitable side effect of cancer treatment druges then the aim of this study was to investigate the possible protective effects of Grape seed extract with potent antioxidant activity, on busulfan-treated adult male mice. Materials and Methods: In thi...