background: mahyaveh is an iranian salted-fermented fish sauce which due to its high amount of protein has risk of histamine production. this study was carried out to determine effect of zataria multiflora essential oil (eo) on histamine production in mahyaveh. methods: dried anchovies (stolephorus sp.), refined-salt and mustard seed (brassica juncea) were purchased from the local market in ban...

Recent studies have shown that cimetidine, burimamide and improgan (also known as SKF92374, a cimetidine congener lacking H2 antagonist activity) induce antinociception after intracerebroventricular administration in rodents. Because these substances closely resemble the structure of histamine (a known mediator of some endogenous analgesic responses), yet no role for known histamine receptors h...

External application of static magnetic fields (SMF), used specifically for the treatment of inflammatory conditions such as soft tissue injuries, has recently become popular as a complementary and/or alternative therapy with minimal investigation into efficacy or mechanism. Localized inflammation was induced via injection of inflammatory agents lambda-carrageenan (CA) or histamine into rat hin...

Histamine and histamine receptors in the central nervous system actively participate in the modulation of motor control. In clinic, histamine-related agents have traditionally been used to treat vestibular disorders. Immunohistochemical studies have revealed a distribution of histaminergic afferents in the brainstem vestibular nuclei, including the lateral vestibular nucleus (LVN), which is cri...

Histidine is an amino acid precursor of neuronal histamine. It is evident that peripheral injection of histidine produces effects that resemble to centrally administered histamine. The aim of the present study was to compare the effects of intracerebroventricular (ICV) injection of histamine and inraperitoneal (IP) injection of histidine on food intake in rabbits. ICV injections of histamine (1...

Background: Thioredoxin (TRX), a 12-kDa oxidoreductase enzyme, is well known to be a redox-active protein that regulates reactive oxidative metabolism. TRX is also accepted to be a protein with anti-inflammatory effects and reported to attenuate the development of allergic airway inflammatory diseases such as allergic rhinitis (AR) and asthma. Although histamine H1 receptor antagonists are freq...

Numerous "antihistamines" as well as various psychotropic medications with antihistamine properties are widely utilized to treat insomnia. Over-the-counter sleep aids usually contain an antihistamine and various antidepressants and antipsychotics with antihistamine properties have sedative-hypnotic actions. Although widely used for the treatment of insomnia, many agents that block the histamine...

regard, the recent article by Yellowlees and Kalucy (Chest 1990; 97:628-34) and the accompanying editorial by Gorman (Chest 1990; 97:514-15) were of great interest. With respect to the apparent efficacy of anti-depressant medications in asthmatic patients, however, it is important to consider the antihistaminic properties (which are not widely appreciated) that these agents possess. Tricyclic a...

OBJECTIVE The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of the NAc is involved in anxiety-related behaviors. METHODS Rats were anesthetized w...