although migraine affects about 15 % of the population, and many studies have been performed to find the mechanism and successful management, the physiopathology of migraine is still largely unknown. the possibility of an ige-mediated allergic mechanism and the role of histamine remains controversial. the aim of the present study was the evaluation of serum total ige and histamine levels in mig...

the aim of this study was to assess the effects of exogenous histamine and h1 and h2 central receptorson electrocardiographic (ecg) parameters, heart rate and mean electrical axis in broiler chickens. for thispurpose, ross broiler chickens (750-800 g weight) received intracerebroventricularly (icv) histamine.moreover, to determine the receptors involved in histamine-induced alterations in ecg c...

We investigated the hypothesis that prior airway muscarinic receptor stimulation (with aerosolized methacholine) would modify the bronchoconstrictor response to histamine, which is, in part, vagally mediated. On four different experiment days, the following combinations of methacholine and histamine inhalation challenges were performed in 15 subjects (nine normal and six asthmatic) in a random ...

The main objective of this study was to investigate the ability of histamine receptor antagonists to modulate tryptase release from human colon mast cells induced by histamine. Enzymatically dispersed cells from human colon were challenged with histamine in the absence or presence of the histamine receptor antagonists, and the tryptase release was determined. It was found that histamine induced...

The role of histamine in acid secretion is controversial. Improvements in the techniques of histamine assay allow a better assessment of the relationship of histamine to acid secretion. Patients with duodenal ulcers were studied to determine the mucosal histamine responses to pentagastrin stimulation to relate the appearance of histamine in the gastric juice to acid production during stimulatio...

Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance di...

foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. this study was designed to assess the antinociceptive effects of aqueousextract of f. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. the results of this study showed that aqueous extract of f. v...

Poisoning due to ingestion of foods with elevated levels of biogenic amines (histamine, putrescine, cadaverine, and tyramine) is well documented. Histamine fish poisoning largely is due to growth of naturally occurring bacteria associated with scombroid fish species. A rapid and reliable method is needed to screen for the presence of histamine-forming bacteria in fish. This study included a com...

In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in the control of basophil functions because exogenous histamine can inhibit its own synthesis--and that of interleukin (IL)-4, IL-6, and IL-13--through this means of transport. Furthermore, ligands o...

Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of foods with high contents of histamine, leading to histamine intoxication. In individuals with histamine intolerance (HIT) ingestion of food with normal contents o...