The utility of tyrosinase minigene co-injection was evaluated as a visual marker for the generation and breeding of transgenic mice. In an evaluation of 39 transgenic founder animals and 44 transgenic lines five phenotypic patterns of pigmentation were consistently observed, including albino, dark, light, mottled and himalayan. In these studies co-injection of the tyrosinase minigene along with...

The Main Central Thrust shear zone is the dominant crustal thickening feature in the Himalayas, largely responsible for the extreme relief and mass wasting of the range. Along the Bhagirathi River in NW India, the Main Central Thrust is several kilometers thick and separates high-grade gneisses of the Greater Himalayan Crystallines from Lesser Himalayan metasedimentary rocks. Th-Pb ion micropro...

Tyrosinase (monophenol monooxygenase; monophenol, L-dopa:oxygen oxidoreductase, EC 1.14.18.1) is a key enzyme in the synthesis of melanin. Reduced levels of tyrosinase play an important role in albinism. The data described here show differences in the expression and characteristics of tyrosinase in cutaneous murine melanocytes grown in culture from normal wild-type strains (C/C); from three alb...

7 The Tertiary continental strata of the Himalayan foreland basin are subdivided in two 8 groups, but the meaning of this subdivision was previously unclear. From the analysis of drill9 holes, seismic lines, dated sections, field outcrops and balanced cross-sections, we find that the 10 southward migration rate of the deposition pinch-out of the younger group is 19 ± 5 mm/yr and 11 equals the H...

The high-altitude transverse valleys [>3,000 m above sea level (masl)] of the Himalayan arc from Arunachal Pradesh to Ladahk were among the last habitable places permanently colonized by prehistoric humans due to the challenges of resource scarcity, cold stress, and hypoxia. The modern populations of these valleys, who share cultural and linguistic affinities with peoples found today on the Tib...

Copy right Idea Grou p Inc. Copy right Idea Grou p Inc. ABSTRACT This paper outlines an ongoing research on the implementation of spatial metadata server for the Hindu-Khus Himalayan region to facilitate spatial data sharing among different regional agencies. As a mainstream of information technology, Geographic Information Systems (GIS) is getting into the core of natural resource planning and...

We analyzed the genetic diversity (V4 region of the 18S rRNA) of planktonic microbial eukaryotes in four high mountain lakes including two remote biogeographic regions (the Himalayan mountains and the European Alps) and distinct habitat types (clear and glacier-fed turbid lakes). The recorded high genetic diversity in these lakes was far beyond of what is described from high mountain lake plank...

Although anecdotally associated with local bears (Ursus arctos and U. thibetanus), the exact identity of 'hominid'-like creatures important to folklore and mythology in the Tibetan Plateau-Himalaya region is still surrounded by mystery. Recently, two purported yeti samples from the Himalayas showed genetic affinity with an ancient polar bear, suggesting they may be from previously unrecognized,...

[1] We introduce a new method that convolves detrital mineral cooling ages with digital elevation models to test numerical models of erosion in collisional orogens. Along a Trans-Himalayan transect in central Nepal, we develop a kinematic and thermal model to predict variations in bedrock cooling ages in modern Himalayan topography. The model assumes a thermal steady state and utilizes a simple...