Abstract It was 40 years ago today, when Ned taught DNA to play [32]. When Seeman began laying the theoretical foundations of what is now nanotechnology, he likely did not imagine entire diversity and scale molecular structures, machines, computing devices that would be enabled by his work. While there are many reasons for success field, least creativity shown community helped build, such progr...

In the past decade, malaria rates have plummeted as a result of aggressive infection control measures and the adoption of artemisinin-based combination therapies (ACTs). However, a potential crisis looms ahead. Treatment failures to standard antimalarial regimens have been reported in Southeast Asia, and devastating consequences are expected if resistance spreads to the African continent. To pr...

Introduction Research on membrane trafficking has generated many key insights into the molecular machinery of individual events. However, comprehensive and quantitative models that describe membrane trafficking in a mammalian cell as one system are lacking. The main workhorses to discover these pathways in this research are mammalian viruses, which have co-evolved with mammalian cells and, ther...

We have investigated two process techniques: resist ashing and oxide hard mask trimming. A combination of ashing and trimming produces sub-30-nm MOSFET gate. These techniques require neither specific equipment nor materials. These can be used to fabricate experimental devices with line width beyond the limit of optical lithography or high-throughput -beam lithography. They provide 25-nm gate pa...

A new asynchronous pipeline scheme (called LPHC), and two new pipelined asynchronous adder implementations, are introduced for high-throughput applications such as DSP’s for multimedia processing. The pipeline scheme is targeted to dynamic datapaths. A novelty of the approach is that it uses decoupled control for pull-up and pull-down stacks. The adders are pipelined at the gate-level and achie...

Diseases are increasingly identified with genetic modules, such as molecular pathways. Pathway-level analysis can provide important insights for making biological inferences and hypothesis from genetic data. The computational approaches for incorporating pathway knowledge to interpret high-throughput datasets play a key role in understanding diseases mechanism from genetic studies. This paper i...

The reliable identification of genes is a challenging and crucial part of genome research. Various methods aiming at accurate predictions have evolved that predict genes ab initio on reference sequences or evidence based with help of additional information. With high-throughput RNA-Seq data reflecting currently expressed genes, a particularly meaningful source of information has become commonly...

Background Gene DNA sequences identified by many genome projects and improvements of nanotechnology have made high-throughput experiments a powerful tool to study the differential expression of thousands of genes at once. Nevertheless, these experiments produce a huge amount of data, quantifying the expression level of each of thousand genes in a number of different tissue types and conditions,...