نتایج جستجو برای: high risk breast cancer
تعداد نتایج: 3546580 فیلتر نتایج به سال:
Background & Objectives: The repression of retinoic acid receptor-β2 (RARβ2) expression is a concerning aspect of breast cancer, which is often induced by hypermethylation at promoter of the gene. We aimed to explore the correlation of plasma folate, vitamin B12 and total homocysteine (tHcy) levels with hypermethylation status of RARβ2 gene among Iranian breast cancer patients. Methods: The...
Background: Breast cancer is one of the most common cancers among women worldwide. Tumor protein 53 (TP53) and its regulator the mouse double murine 2 (MDM2) have important roles in tumorigenesis by playing key roles in cell division and response to DNA damage. MDM2 SNP309 T>G (rs2279744) polymorphism in the promoter region of MDM2 gene can cause dysfunction and inactivation of TP53 which promo...
Background: Breast cancer is the most common cancer among females in the world. Identifying the nutrients that modify the risk of the disease is one of the key strategies for improving the quality of life and reducing treatment costs. Epidemiological studies support the role of macronutrients and vitamins involved in one carbon metabolism in the etiology of the disease. This study aimed in inve...
Breast cancer affects Iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in Tehran. Thisstudy aimed to compare the AhR levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. Possible associations of AhR with lifestyle and reproductive risk factorsand ...
introduction: the etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. it seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. the aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (er) and progesterone receptor (pr...
Reduction mammaplasty is increasingly used for the treatment of discomfort associated with macromastia. Breast cancer is a tumor with the highest prevalence and incidence in women. As it can be expected, reduction mammaplasty specimens occasionally reveal breast cancer. So, before reduction mammaplasty, patients should be assessed for breast cancer risk and evaluated by physical examination a...
background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...
Background: Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. This case-control study investigated the relationship between menstrual factors and risk of breast cancer incidence in Iranian Center for Breast Cancer (ICBC). Materials and Methods: Forty seven Cases of breast cancer referred to ICBC and 77 controls were studie...
Background and purpose: Breast cancer is one of the most common cancers in women all over the world. The death rate of this cancer is also increasing. It seems that medication is related to this cancer. The present study aimed at estimating the risk of this cancer using Gail Model and its relationship with medication in women. Materials and Methods: In this cross-sectional study, 260 35-year-o...
adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. the action of adiponectin is via binding to main receptors. it has several actions including regulation of glucose level, lipid homeostasis and reproductive system. adiponectin can also influence vascular endothelium via preventing the migration of monocytes. the rol...
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