نتایج جستجو برای: hey1

تعداد نتایج: 234  

Journal: :Oncotarget 2015
Menaka C Thounaojam Duafalia F Dudimah Samuel T Pellom Roman V Uzhachenko David P Carbone Mikhail M Dikov Anil Shanker

The immunosuppressive tumor microenvironment usurps host antitumor immunity by multiple mechanisms including interference with the Notch system, which is important for various metazoan cell fate decisions and hematopoietic cell differentiation and function. We observed that treatment with the proteasome inhibitor bortezomib in mice bearing various solid tumors resulted in an upregulated express...

2015
Persefoni Fragkiadaki Nikolaos Soulitzis Stavros Sifakis Demetrios Koutroulakis Victor Gourvas Nikolaos Vrachnis Demetrios A. Spandidos

Preeclampsia (PE) is a major cause of maternal mortality and morbidity, affecting 3-5% of all pregnancies. The Notch signaling pathway plays an important role during placental development, activating several target genes. Defects in the Notch pathway have adverse effect on placentation. The aim of this study was to investigate the expression of receptors NOTCH1,-2,-3,-4, ligands DLL1,-3,-4, JAG...

Journal: :The Journal of biological chemistry 2014
Peng-Fei Zhai Fang Wang Rui Su Hai-Shuang Lin Chong-Liang Jiang Gui-Hua Yang Jia Yu Jun-Wu Zhang

Emerging evidence has shown that microRNAs have key roles in regulating various normal physiological processes, whereas their deregulated expression is correlated with various diseases. The miR-146 family includes miR-146a and miR-146b, with a distinct expression spectrum in different hematopoietic cells. Recent work indicated that miR-146a has a close relationship with inflammation and autoimm...

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