PURPOSE To assess the role of regional cerebral blood flow measured by technetium-99m hexamethyl propyleneamine oxime (HMPAO) brain single-photon emission CT (SPECT) in viral encephalitis of children. METHODS Eighteen children diagnosed as having viral encephalitis (12 Epstein-Barr virus, 4 herpes simplex virus, and 2 Japanese B virus) underwent Tc-99m HMPAO brain SPECT and brain MR and/or CT...

UNLABELLED Strategies to promote angiogenesis can benefit cerebral ischemia. We determined whether liposomal delivery of angiogenic peptides with a known biologic activity of vascular endothelial growth factor benefitted cerebral ischemia. Also, the study examined the potential of (18)F-FDG PET imaging in ischemic stroke treatment. METHODS Male Sprague-Dawley rats (n = 40) underwent 40 min of...

W e want to report an error in interpreting d,l-hexamethylpropylene amine oxime (HMPAO) tomograms as cerebral blood flow (CBF) in subacute ischemic stroke cases. By simultaneously studying CBF by `33Xe dynamic single-photon emission computed tomography (SPECT), an obvious discrepancy was noted in that the HMPAO tomograms grossly exaggerated the reflow hyperemia following spontaneous reperfusion...

In-vitro labeling of RBC with (99m)Tc is an intricate procedure and there is always a need for an alternate blood pool imaging agent. The aim of this study was to prepare an effective nano sized liposome (NLs) similar to human RBC for blood pool scintigraphy. This study formulates PEG-NLs and non-PEG-NLs using film method plus high pressure homogenization technique. Biodistribution studies were...

Objectives—Firstly, to compare the findings of interictal F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and of single photon emission computed tomography (SPECT) using Tc-hexamethyl propylene-amine-oxime (HMPAO) and I-iomazenil in localising the epileptogenic cortex in patients who were candidates for epilepsy surgery, but in whom clinical findings, video EEG monitoring (V-EEG),...

OBJECTIVE In this study, we employed technetium-99m hexamethylpropylene amine oxime (99mTc HMPAO) lung scan to detect inhalation lung injury of patients after a fire accident. METHODS Ten healthy men for controls and 10 male patients with pulmonary symptoms/signs from a fire accident were enrolled in this study for comparison. 99mTc HMPAO lung scan was performed in each control and patient, a...

OBJECTIVE (99m)Tc labeled hexamethylpropylene amine oxime (HMPAO) white blood cell (WBC) scintigraphy is a frequently used option for acute infection, particularly in pediatric patients. This scintigraphy is applied to detect sites of infection/inflammation in patients with fever of unknown origin, to find and follow up osteomyelitis, and to detect suspicion of acute appendicitis. The aim of th...

Accurate epileptic focus localization using single photon emission computed tomography (SPECT) images has proven to be a challenging endeavor. First, commonly used radiopharmaceuticals such as hexamethylpropylene amine oxime (HMPAO) quantitatively underestimate large blood flows, leading to subtracted SPECT images that do not reflect the true cerebral physiological conditions, and often display...

OBJECTIVES Most studies that clinically validated peri-ictal SPECT in intractable partial epilepsy had used technetium-99m-hexamethylpropylene amine oxime (99mTc-HMPAO or 99mTc-exametazime) as the radiopharmaceutical. Because of some theoretical advantages, technetium-99m-ethyl cysteinate diethylester (99mTc-ECD or 99mTc-bicisate) is increasingly being used instead. This study compares unstabil...