Osseous metaplasia is a phenomenon which is described in a variety of tissue types with respect to both neoplastic and non-neoplastic conditions. In the gastrointestinal tract, osseous metaplasia (heterotopic bone formation) is rarely detected. Most of the reported cases were associated with malignant lesions. Here, we are reporting a rare case of a juvenile rectal polyp in a 14 years male, whi...

RATIONALE Heterotopic gastric mucosa has been described at various locations of the body; however, the polyp composed of heterotopic gastric mucosa in the small intestine is rare. PATIENT CONCERNS A 15-year-old boy visited us for investigation of recurrent episodes of melena. Capsule endoscopy (CE) revealed a polypoid tumor in the ileum, with an active nearby hemorrhage. Contrast-enhanced com...

Using a computer database, the author investigated the histopathology of 10 000 consecutive gastric specimens, taken in the last 12 years (2002-2013) at the pathology laboratory of a Japanese hospital. Re-observation of the already examined histological sections was done when the histological diagnosis and findings on the computer data base were not very obvious. The gastric specimens were iden...

BACKGROUND Several animal models have been established to investigate the mechanisms of obliterative bronchiolitis after lung transplantation. In this study, we compared three prevalent murine models of obliterative bronchiolitis in terms of several basic pathologic changes in a relatively short span of time after transplantation. METHODS Each of the recipient mice simultaneously received ort...

The finding of ectopic gastric mucosa is well documented throughout the gastrointestinal tract from the tongue to the rectum. Its presence within the gallbladder and the biliary tree is extremely rare and most probably secondary to an aberrant histogenesis. This brief report presents the second reported case of heterotopic gastric tissue within the common bile duct. A literature review, brief o...

A heterotopic pancreas in the gastrointestinal tract is mostly found incidentally and its malignant transformation is extremely rare. We describe the second case of adenocarcinoma arising in a gastric heterotopic pancreas of an asymptomatic 35-yr-old man in Korea. Esophagogastroduodenoscopy revealed a submucosal tumor with an irregular central umbilication in the gastric antrum. A wedge resecti...

Thirteen patients are described who, on routine endoscopy of the upper gastrointestinal (GI) tract, were found to show a characteristic appearance in the proximal duodenum. This consisted of multiple small mucosal nodules, predominantly in the anterior wall. All cases were biopsied, and showed identical histological appearances of heterotopic gastric mucosa of body type. The incidence of this c...

Ectomesenchyme, a derivative of the embryonic neural crest, forms the membrane bones of the mandibular skeleton, but will only do so after undergoing an inductive interaction with mandibular epithelium. Previously, non-mandibular epithelia have been shown to act as effective substitutes for the mandibular epithelium in this interaction. The role of epithelial viability was examined by enzymatic...

Despite serving as the primary entry portal for coxsackievirus B (CVB), little is known about CVB infection of the intestinal epithelium, owing at least in part to the lack of suitable in vivo models and the inability of cultured cells to recapitulate the complexity and structure associated with the gastrointestinal (GI) tract. Here, we report on the development of a three-dimensional (3-D) org...