acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...

BACKGROUND After allogeneic hematopoietic stem-cell transplantation patients are at increased risk for herpes zoster as long as varicella-zoster virus specific T-cell reconstitution is impaired. This study aimed to identify immunodominant varicella-zoster virus antigens that drive recovery of virus-specific T cells after transplantation. DESIGN AND METHODS Antigens were purified from a varice...

The activities ofdCMP deaminase andDNA polymerase I increased twofold and fivefold in BHK-21/C13 cells after infection by the virus of herpes simplex. The increases were greatly diminished, and under certain conditions prevented, by inclusion of actinomycin D or cycloheximide in the cell-virus system during the infective cycle. ThedCMP deaminase purified from infected cells harvested 8h after i...

The seroprevalence of B Virus (BV, Macacine herpesvirus 1) in bred cynomolgus monkeys (Macaca fascicularis) in Cambodia was investigated. Blood samples were collected by venous puncture between 2007 and 2011, and a commercially available enzyme-linked immunosorbent assay (ELISA) kit was used to detect IgG antibodies against BV. A total of 1710 blood samples were examined, and the overall preval...

Methanolic extracts of 41 plant species belonging to 27 families used in the traditional medicine in Nepal have been investigated for in vitro antiviral activity against Herpes simplex virus type 1 (HSV-1) and influenza virus A by dye uptake assay in the systems HSV-1/Vero cells and influenza virus A/MDCK cells. The extracts of Astilbe rivularis, Bergenia ciliata, Cassiope fastigiata and Thymus...

BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effect of Berberis vulgaris (BV) juice consumption on insulin homeostasis, glycemic profiles of patients with benign breast disease (BBD). SUBJECTS/METHODS: This parallel design, triple-blind, randomized and placebo controlled clinical trial was conducted on 85 eligible women diagnosed with BBD who recruited from Nour-Nejat hos...

The microbiological and epidemiological correlates of vaginal colonisation by Mobiluncus species were examined among randomly selected women attending a sexually transmitted disease (STD) clinic. Women positive for Trichomonas vaginalis were excluded. Mobiluncus spp. were detected by Gram stained vaginal smear in 21% of 633 STD clinic patients, including 53% of those with and 4% of those withou...

Background and Aims: Herpes simplex virus type 1 (HSV-1) belonging to herpes viridae family is a normal human pathogen with benign lesions in immunocompromised patients which creates serious problems. Acyclovir is used to treat herpetic infections. Because of developing drug-resistant strains, the use of medicinal plants and their related compounds with fewer side effects is considered for the ...

We have reported previously (H. R. Kotilainen, J. P. Brinker, J. L. Avato, and N. M. Gantz, Arch. Intern. Med. 149:2749-2753, 1989) that the quality of nonsterile examination gloves available for clinical use may be extremely variable. In view of the concern over human immunodeficiency virus and hepatitis B virus transmission to health care workers, the continuing variability of gloves availabl...