It is now possible to identify acquired and hereditary risk factors in a substantial percentage of patients presenting with a venous thrombotic event. Discovery of the factor V Leiden and prothrombin G20210A mutations has greatly increased the percentage of patients in whom venous thrombosis can be attributed to hereditary thrombophilia. There is, however, considerable uncertainty as to how thi...

May-Hegglin anomaly is a hereditary thrombocytopenia associated with giant platelets and large basophilic, cytoplasmic inclusion bodies (resembling Döhle bodies) in the granulocytes. Patients may experience easy bruising, recurrent epistaxis, gingival bleeding, menorrhagia and sometimes excessive bleeding associated with surgical procedures. Failure to appropriately diagnose May-Hegglin anomaly...

INTRODUCTION: Peutz-Jeghers syndrome (PJS) is a rare (orphan) hereditary disease with family history, primarily characterized by massive polyposis of the gastrointestinal tract and its complications. Every year, registered in 1 patient per 25,000–300,000 population. OBJECTIVE: To demonstrate effectiveness combined use diagnostic radiology endoscopic imaging techniques diagnosis this A case repo...

Rendu-Osler-Weber disease, also called hereditary hemorrhagic telangiectasia (HHT), is a rare, genetically determined complex disease with a spectrum of associated manifestations which extend beyond the typical pathology of arteriovenosus malformations (AVMs). Our subject, a 54-year-old male patient with a long history of HHT has a typical mucocutaneous telangiectasias and bleeding from the nos...

Orthodontic treatment is fully consistent with general health and it also improves quality-of life along with psychological considerations. Haemophilia is a disorder in which due to deficiency of some coagulation factors. Hereditary deficiency of coagulation factors has caused 90% of hereditary diseases: Haemophilia A, Haemophilia B and von Willebrand’s. Two issues need to be considered in the ...

Hereditary deficiency of the macromolecular Factor VIII complex results in classic von Willebrand disease in man and animals, a bleeder state characterized by loss of the multiple biologic activities associated with the Factor VIII complex, including the platelet-aggregating von Willebrand factor. The bleeding time is also long. Venom coagglutinin, a Bothrops factor that causes platelet aggrega...

background : rectal bleeding is a relatively uncommon, but potentially important problem in early infancy.  the common causes of fresh rectal bleeding in this age group are: bleeding diathesis (vit. k deficiency), infectious colitis, cow’s milk protein allergy and anal fissure.  nodular lymphoid hyperplasia (nlh) is another cause of prolonged fresh rectal bleeding in early infancy.   objective:...

I Hereditary hemorrhagic telangectasia (HHT) or Rendu-Osler-Weber syndrome is characterized for fibromuscular dysplasia of the terminals vessels that propitiate the development of vascular ectasias and arteriovenous malformations. The mucosae, skin, lung and brain are the most commonly affected organs. This article describes a case of HHT an adult patient associated with multiple angiodysplasic...