The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.

New continuous group transforms, together with their discretization over a lattice of any density and admissible symmetry, are defined for a general compact simple Lie groups of rank 2 ≤ n < ∞. Rank 1 transforms are known. Rank 2 exposition of Cand S-transforms is in the literature. The E-transforms appear here for the first time.

A new type of high-throughput and parallel optical sensing platform with a single-color probe based on microfluidic chip electrophoresis combined with aptamer-carboxyfluorescein/graphene oxide energy transfer is reported here. Label-free protein multi-targets were detected, even in challenging complex samples without any pre-treatment.

The current study investigated the effects of oral code-mixing and glossing on L2 vocabulary learning. To this end, 60 EFL learners studying at pre-university school were given a pre-test to make sure that they did not have any prior knowledge of the target words. Based on their scores in the pre-test, 36 pre-university students were selected and divided into three groups, including two experim...

Is it possible to use convolutional neural networks pre-trained without any natural images assist image understanding? The paper proposes a novel concept, Formula-driven Supervised Learning. We automatically generate patterns and their category labels by assigning fractals, which are based on law existing in the background knowledge of real world. Theoretically, generated instead pre-training p...

Although we have tons of machine learning tools to analyze data, most of them require users have some programming backgrounds. Here we introduce a SaaS application which allows users analyze their data without any coding and even without any knowledge of machine learning. Users can upload, train, predict and download their data by simply clicks their mouses. Our system uses data pre-processor a...