The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impaired in the rat on either an iron deficient or a protein deficient diet. Further...

tal infection of the Mongolian gerbil (Meriones unguiculatus) with Trichostrongylus axei. J. Parasit. 47 (4, sec. 2 ) : 19. . 1963a. Studies on Trichostrongylus axei (Cobbold, 1879). VIII. Some quantitative aspects of experimental infection of the Mongolian gerbil (Meriones unguiculatus). J. Parasit. 49: 617-622. . 1963b. Preliminary evaluation of Trichostrongylus axei in the Mongolian gerbil a...

INTRODUCTION The problem of anthelmintic resistance in gastrointestinal nematodes (GIN) of small ruminants is world wide in distribution. In the past 20 years no new classes of anthelmintics have been developed for use in animals. Anthelmintic resistance has been documented to all classes of anthelmntics and multi-class resistance exists in many flocks. The challenge to veterinarians and produc...

The scientific meeting entitled 'Anthelmintics: From Discovery to Resistance' was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites were covered in the oral and poster presentations. The attendees were from both academic and industrial backgrounds. In the present article we introduce a numbe...

AIM Gastrointestinal (GI) nematodes are considered as a major constraint for successful sheep production. Control of these parasites heavily relies on the use of chemical anthelmintics. Over the past decades, the development of anthelmintic resistance to various groups of anthelmintics and problem of drug residues in animal products has awakened interest in medicinal plants as an alternative so...

The increasing prevalence of resistance to anthelmintics among gastrointestinal nematodes and the desire for lower input agriculture have promoted the idea that targeted selective treatment (treating the animals in need of such a treatment and only them) could be a sustainable solution for controlling internal parasites of ruminants. The pros are the slowing of resistance prevalence, lower resi...

Oesophagostomum bifurcum has recently been recognized as a common parasite of man in northern Togo and in Ghana. In a preliminary trial several anthelmintics were evaluated in the treatment of mixed Oesophagostomum and hookworm infections. Diagnosis was based on faecal culture, since the eggs of Oesophagostomum and hookworm cannot be distinguished morphologically. Of the anthelmintics tested, a...

Chemotherapy remains the foremost available tool for the control of nematode parasites. However, the substantial use of anthelmintics, combined with a scarcity of new anthelmintic classes, has led to a gradual increase in the resistance of nematode parasites to these compounds. Multi-Drug Resistance (MDR) in economically important livestock nematodes, such as Haemonchus contortus enables the pa...

In present research study, three experiments were launched during January 2011 to December 2011. Experiment I, Epidemiology: A total 1200 faecal samples (100 per month) were collected from farmers Bibrik-sheep (either sexes, 1-5 years old) and analyzed for nematodes prevalence. Experiment II, Sero-diagnosis: The sera samples of healthy and nematodes infected sheep were analyzed through ELISA. E...