Hepatocellular carcinoma (HCC) is one of the most common cancers and main cause cancer-related death globally. Immune dysregulation CD4+ T cells has been identified to play a role in development HCC. Nevertheless, underlying molecular pathways HCC are not completely known. Thus, better understanding lncRNA-miRNA/mRNA network may yield novel insights into etiology or progression In this study, c...

discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

Hepatocellular carcinoma (HCC) is highly associated with inflammation. Myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells, are abundant in the HCC microenvironment and are often associated with poor prognosis. Myeloid cells in HCC play a vital role in supporting tumor initiation, progression, angiogenesis, metastasis, and therapeutic resistance. Here, we ...

Abstract Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods We used the combination computational experimental approaches to discover a CDK2/4/6 triple-inhibitor from FDA approved small-molecule drugs for treatment HCC. Results identified vanoxerine dihydrochloride a...

BACKGROUND In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in promoting development of HCC. Evidence is accumulating that members of the chemokine receptor family are viewed as promising therapeutic targets in the fight against cancer. More ...

Abstract Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker its clinical significance We compared sFABP5 concentration patients with (HCC group) that hepatitis without (hepatitis group). Moreover, measured expression levels resected (...

Hepatocellular carcinoma (HCC) accounts for 85% of primary liver cancer, the third most common cause cancer-related deaths worldwide. Its incidence has been increasing in both men and women. In Western countries, high-calorie diets, mainly rich carbohydrates such as fructose, represent a significant concern due to their repercussions on population’s health. A high-fructose diet is related devel...

Angiogenesis plays a crucial role in the development of human hepatocellular carcinoma (HCC). In the present study, we found a natural compound, deguelin, has a profound anti-angiogenesis effect on HCC. Deguelin suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in...

contexts hepatocellular carcinoma (hcc) is one of the most common malignant diseases in the world. because less than 20% of patients with hcc are resectable, various types of non-surgical treatment have been developed. evidence acquisition at present, radiofrequency ablation (rfa) is accepted as the standard local treatment for patients with hcc because of its superior local control and overall...

Common techniques for the treatment of Hepatocellular carcinoma (HCC) have not been successful, and thus the design and discovery of new compounds with better anti-cancer function are needed. Snake venom is among the most important compounds used by researchers to the treatment of various cancers. This study was designed to evaluate the toxicity effect of Persian Gulf snake venom (Enhydrina sch...