Increased liver enzyme activities are sensitive indicators of primary hepatic disease, but they are also associated with extrahepatic diseases. The patient's signalment, clinical status, and pattern of liver enzyme activity can help in interpreting findings. The three basic liver enzyme patterns are (1) cholestatic, (2) hepatocellular leakage, and (3) mixed. Predominant increases in the activit...

has previously been isolated by Horecker (1) from an acetone powder of liver and characterized as a flavoprotein. It was initially suggested that this enzyme was localized in hepatic mitochondria. However, subsequent studies have revealed that triphosphopyridine nucleotide-cytochrome c reductase activity is also present in hepatic microsomes (a), and it has been reported that the properties of ...

Phenylalanine hydroxylase (Ec 1.14.16.1) catalyses the initial step of phenylalanine degradation in man and other mammals. Although the liver is the primary location of the enzyme, an appreciable amount is also found in the renal cortex [I]. The regulatory properties of the hepatic enzyme are well known. In the short-term, enzymic activity is controlled by reversible phosphorylation [2]. Glucag...

Rats were given a single dose of toxaphene (120 mg/kg, equivalent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. Liver weight and hepatic microsomal enzyme activity were increased at day 5 and 15. The level of plasma testosterone was significantly decreased at day 15. In a second experiment rats were given 2.4 mg/kg daily and sacrificed at 1, 3 and 6 months. Liver weight and microsomal enzym...

We have studied 250 human liver biopsy samples to determine the ontogeny of the microsomal glucose-6-phosphatase (EC 3.1.3.9) system. Human hepatic glucose-6-phosphatase enzyme activity develops at 11 weeks' gestation and slowly increases to approximately 10% of adult activity at term. In the first week after birth, activity rises to adult values. Increases in enzyme activity coincide with incr...