OBJECTIVE To compare the positive and negative effects of rifaximin and nonabsorbable disaccharides in patients with hepatic encephalopathy. METHODS We used the method recommended by The Cochrane Collaboration to perform a meta-analysis of comparative randomized trials of rifaximin and nonabsorbable disaccharides. RESULTS Seven randomized controlled trials were identified, but only five tri...

Hepatic encephalopathy is a major complication of acute and chronic liver disease. This neuropsychiatric syndrome presents clinically with abnormalities in mental status and neuromotor function. Symptoms exist on a spectrum ranging from subtle deficits in attentiveness to severe confusion and even coma. The pathogenesis of this disease is not fully understood, but the accumulation of gut-derive...

Mol. Nutr. Food Res. 2023, 67, 202200158 DOI: 10.1002/mnfr.202200158 Hepatic encephalopathy (HE) is a neurotoxic disease with spectrum of neuropsychiatric abnormalities that develops as result hepatic dysfunction. Chitooligosaccharides (COS) an oligosaccharide possesses prominent biological activities including incalculable hepatoprotective and neuroprotective effects. Here, COS has been proved...

OBJECTIVE As acute liver failure (ALF) and chronic liver disease (cirrhosis) continue to increase in prevalence, we will see more cases of hepatic encephalopathy. Primary care physician are often the first to suspect it, since they are familiar with the patient's usual physical and mental status. This serious complication typically occurs in patients with severe comorbidities and needs multidis...

Abhinay Reddy Koppula, Dudekonda Sai Sandeep and Tekuru Yogesh Hepatic Encephalopathy (H.E), defined as a spectrum of neuropsychiatric abnormalities in patients with severe liver dysfunction. It is most common complication advanced disease significant incidence death rate [1].