OBJECTIVE The goal was to test the effects of high-efficiency, particulate-arresting (HEPA) air cleaners on unscheduled asthma visits and symptoms among children with asthma exposed to secondhand smoke. METHODS We enrolled 225 eligible children who were 6 to 12 years of age, had physician-diagnosed asthma, and were exposed to ≥5 cigarettes per day. We conducted a double-blind, randomized tria...

Hepatitis A can cause serious illness among adolescents and adults with low vaccination coverage. Even though hepatitis A vaccine is one of the strong candidates for Korean national immunization program, adolescents aged older than 12 yr would not benefit. Our purpose was to assess the willingness and analyze the correlates of Korean mothers for hepatitis A (HepA) vaccination to develop strateg...

The COVID-19 pandemic triggered the widespread use and need for respirators face masks healthcare workers public. In this study, several generally available mask designs were fit tested, their materials evaluated filtration efficiency using 250 nm polystyrene latex particles. Efficiency testing was performed 2 0.5 h at low (2.6 L min–1) high (7.4 airflows, respectively, ~17.4 cm2 material area....

To evaluate the effect of a room high-efficiency particulate air (HEPA) cleaner on cat-induced asthma and rhinitis, 35 cat-allergic subjects who were living with one or more cats were studied in a double-blind, placebo controlled trial. After a 1 mo baseline period, subjects' bedrooms were equipped with an active or placebo air cleaner for the following 3 mo. Evaluations included monthly measur...

Although liver fibrosis reflects disease severity in chronic hepatitis patients, there has been no simple and accurate system to evaluate the therapeutic effect based on fibrosis. We developed a glycan-based immunoassay, FastLec-Hepa, to fill this unmet need. FastLec-Hepa automatically detects unique fibrosis-related glyco-alteration in serum hyperglycosylated Mac-2 binding protein within 20 mi...

Current airway dust ®lter technology emanates from the USA mining industry during the 1930s. It was further developed and improved by the USA military during World War II to prevent workers from inhaling very ®ne radioactive particles in the nuclear industry. These later ®lters we now recognize as high ef®ciency particulate air ®lters (HEPA). The ef®ciency of ®lters varies according to the numb...

People living in metropolitan cities have to make their way anywhere through traffic every day. In areas like signals, narrow roads, bazars etc., there is a very high concentration of air pollutants due automobile emissions. The pollution these days serious environmental concern. Faster escape solutions are required than permanent over the time changing solutions. some Delhi quality index has r...

3 Acknowledgements T he author would like to express his thanks to the following for their support in creating the Guidelines: Ilkka Vuori, Pekka Oja and Saila Pitkänen for their vision, energy and organisation to develop the idea; Gill Cowburn for her support and input into the research, workshop facilitation and drafting of the Guidelines; the representatives of the four HEPA programmes: Mari...

The aim of this study was to examine the effects of immobilizing rhPDGF-BB plus rhBMP-2 on heparinized-Ti implants on in vivo osseointegration and vertical bone regeneration at alveolar ridges. Successful immobilizations of rhPDGF-BB and/or rhBMP-2 onto heparinized-Ti (Hepa/Ti) were confirmed by in vitro analysis, and both growth factors were found to be sustained release. To evaluate bone rege...

Nuclear factor kappaB (NF-kappaB) is one of the main transcription factors involved in regulating apoptosis, inflammation, chronic liver disease, and cancer progression. The IKK complex mediates NF-kappaB activation and deletion of its regulatory subunit NEMO in hepatocytes (NEMO(Delta hepa)) triggers chronic inflammation and spontaneous hepatocellular carcinoma development. We show that NEMO(D...