Essential thrombocythemia is a myeloproliferative disorder with an increased amount of abnormal platelets, causing both hemorrhagic and thrombotic pathology. Some of its systemic complications include deep vein thrombosis, pulmonary emboli, myocardial infarcts, and renal vessel thrombosis among others. We present the rare case of a woman suffering from essential thrombocythemia with the sudden ...

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder. Dysfunction of cytotoxic T and natural killer (NK) cells causes uncontrolled activity of lymphocytes and histiocytes which leads to HLH. Infections, malignancies, and autoimmune disorders are associated with development of HLH. Dengue and Plasmodium vivax are rare causes of HLH. We report the first ever case of a young man who develop...

Cyclophosphamide is a potent cytotoxic agent used in many clinical settings. The main risks of cyclophosphamide therapy include hematological disorders, infertility, hemorrhagic cystitis and malignancies. Gastrointestinal side effects reported to date are often non-specific and not severe. We present the first case of a fatal small bowel enteritis and pan-colitis which appears to be associated ...

Introduction Placental mesenchymal dysplasia is a rare vascular disease associated with intrauterine growth restriction, fetal demise as well as Beckwith-Wiedemann syndrome. Some neonates present hematologic abnormalities possibly related to consumptive coagulopathy and hemolytic anemia in the placental circulation. Case report We present a case of placental mesenchymal dysplasia in a fetus wit...

Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy duri...

Defects of hemostasis in patients with cancer have been first described by Trousseau in 1865, and Morrison studied altered coagulation in patients with malignancy as early as 1932. The first described abnormality of hemostasis in malignancy was that of hypercoagulability and thrombosis and the first large survey of blood changes in cancer patients showed accelerated bleeding times in over 60% o...

The caudate nucleus (CN) is composed of a head, body and tail. The head of the CN contributes to forming the floor of the lateral ventricle frontal horn. Moreover, the head, which is medially separated by the septum pellucidum extends beyond the anterior part of the thalamus, stroking the telencephalic cortex. The superior part of the head is covered by the knee of the corpus callosum, while th...

After publication of the results of the National Institute of Neurological Disorders and Stroke study, the application of intravenous thrombolysis for ischemic stroke was launched and has now been in use for more than 10 years. The approval of this drug represented only the first step of the therapeutic approach to this pathology. Despite proven efficacy, concerns remain regarding the safety of...

Circulatory disorders, cerebrovascular diseases and hemorrhagic stroke are associated with pregnancy, delivery and puerperium [1-3]. In the Western world, maternal aneurismal subarachnoid hemorrhage (SAH) occurs in 8 – 31 per 100,000 deliveries [4] and accounts for up to 10% of maternal deaths in pregnant women [5]. In an epidemiological survey Jung et al. [1] investigated a history of hyperten...

Two hundred and thirty-one patients with cerebrovascular disease were examined by spectrophotometry of the cerebrospinal fluid (CSF) and by computer tomography. Many were followed by repeated examinations. Specific diagnoses — bleeding as opposed to non-hemorrhagic or hemorrhagic infarctions — were indicated in 97% by spectrophotometry and in 65% by CT scan in 201 of the 231 cases (excluding 25...