hemolytic anemia is exceedingly rare and an underestimated complication after aortic valve replacement (avr).the mechanism responsible for hemolysis most commonly involves a regurgitated flow or jet that related to paravalvar leak or turbulence of subvalvar stenosis. it appears to be independent of its severity as assessed by echocardiography. we present a case of a 24-year-old man with a histo...

Autoimmune hemolytic anemia (AIHA) is a condition in which self-antibodies bound to antigens on the membranes of red blood cells initiate their destruction (hemolysis) via the complement and reticuloendothelial systems. Multiple myeloma (MM), on the other hand, is characterized by a clonal expansion of plasma cells in bone marrow, causing bone tissue destruction, renal failure and hematopoietic...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare chronic hemolytic anemia characterized by an acquired defect of the erythrocyte which renders it susceptible to hemolysis by normal human serum. Previous reports have indicated that magnesium and factors resembling the components of complement are required for the hemolysis in vitro of PNH erythrocytes by normal serum (1, 2). Recently a natura...

BACKGROUND The aim was to reveal the mechanism of hemolysis-induced acute pancreatitis and to evaluate the role of heme and heme oxygenase activity in inducing pancreatic inflammation in an experimental hemolysis model. MATERIAL/METHODS Hemolytic anemia was induced in rats by intraperitoneal injection of 60 mg/kg acetylphenylhydrazine (APH). To evaluate the toxic effect of free heme after hem...

There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell a...

By S. H. Liu, I\I.I). I N ‘FilE preceding paper,’ the diata of 2 cases of chronic anemia of the henlolytic type were presented. The erythrocytes in these cases were abnormally suseeptil)le to hemolysis by chilling and by addition of acid! in the presence of the patients’ as well as control sera. Erythrocytes from control subjects, in contrast, \V(9P not hemolvzed under identical t reat ment . T...

Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. While significant associations were found in HbSS and HbSβ(0) (sickle cell anemia) patients with and without controlling for covariates bet...

A patient with a pure seminoma presented with severe IgG-mediated warm autoimmune hemolytic anemia. Monoclonal IgM-kappa cryoglobulinemia and a biological false positive test for syphilis were also found. Treatment directed at both the seminoma and the hemolysis resulted in the complete disappearance of these antibodies. It is possible that these immunological phenomena occurred in response to ...

By S. H. Liu, I\I.I). I N ‘FilE preceding paper,’ the diata of 2 cases of chronic anemia of the henlolytic type were presented. The erythrocytes in these cases were abnormally suseeptil)le to hemolysis by chilling and by addition of acid! in the presence of the patients’ as well as control sera. Erythrocytes from control subjects, in contrast, \V(9P not hemolvzed under identical t reat ment . T...

Auto-immun events are rare in multiple myeloma (MM). Here, we report one MM case complicated by Evans syndrome (Autoimmun hemolytic anemia (AIHA) associated with thrombocytopenia). A 52-year-old man was admitted in nephrology department with severe anemia, renal insufficiency and hypergamma globulinemia. Laboratory exams showed acute hemolysis due to an IgG warm autoantibody. Serum electrophore...