Sickle cell disease is one of the most common hemoglobinopathy worldwide. It an autosomal recessive genetic disorder caused by replacement adenine to thymine nucleotide in beta chain hemoglobin results valine for glutamic acid at 6th position. This substitution formation sickle (HbS) which turn leads a reduced lifespan red blood cells (RBC). In hypoxic conditions, HbS has tendency aggregate and...

Sickle cell disease (SCD) is the most commonly inherited hemoglobinopathy in the United States. Blood transfusion is a critical part of the multidisciplinary approach necessary in the management of SCD; however, blood transfusions are not without complications. The successful use of transfusion as a treatment strategy in SCD requires the critical review and knowledge of transfusion methods, gen...

Duran Canatan1, Yeşim Aydınok2, Yurdanur Kılınç3, Zeynep Karakaş4, İlgen Şaşmaz3, Hilmi Apak5, Nazan Sarper6 1Mediterranean Blood Diseases Foundation, Hemoglobinopathy Diagnosis Center, Antalya, Turkey 2Ege University, Department of Pediatric Hematology, İzmir, Turkey 3Çukurova University, Department of Pediatric Hematology, Adana, Turkey 4İstanbul University, Çapa Medical Faculty, Department o...

Ayça Dilruba Aslanger1, Aynur Akbulut2, Gül Tokgöz3, Sakine Türkmen4, Kanay Yararbaş5 1 Kocaeli Derince Training and Research Hospital, Medical Genetics Department, Kocaeli, Turkey 2 Kocaeli Derince Training and Research Hospital, Department of Pediatrics, Kocaeli, Turkey 3 Kocaeli Derince Training and Research Hospital, Department of Hematology, Kocaeli, Turkey 4 Hemoglobinopathy Screening Cen...