Conflict of Interest: The authors of this paper have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included. References 1. Harteveld CL, Higgs DR. Alpha-thalassaemia. Orphanet J Rare Dis 2010;5:13. 2. Blackwell RQ, Jim RT, Tan TG, Weng MI, Liu CS, Wang CL. Hemoglobin G Waimanalo: alpha-64 Asp lead...

The reactivity of the iron in the four hemes of the mammalian hemoglobin molecule depends largely on the interactions between the prosthetic groups and the amino acid chains of the globin (1, 2). Normal configuration of heme groups in the abnormal human hemoglobins, therefore, does not preclude anomalies of their oxygen affinity which might arise from aberrations in the globin. In most of the m...

The interaction of cell-free hemoglobin with lipopolysaccharide (LPS) is thought to aggravate the pathophysiology of sepsis and/or septic shock. This study examines the possible modulatory role of cell-free hemoglobin on LPS-induced apoptosis of cultured bovine aortic endothelial cells. Experiments were performed with or without fetal bovine serum, a source of LPS-binding protein and soluble CD...

In Wireless Sensor Network (WSN), congestion must be tackled with sense of urgency. Due to the fact that there is limited memory, battery and less computational capability. Time sensitive application such as battlefield would require efficient transfer of data in order to maintain energy efficiency state of the sensors. WSN current Transport Control Protocols (WSNCP) have been critically scruti...

3. Perrine SP, Greene MF, Failer DV. Delay in the fetal globin switch in infants of diabetic mothers. N Engl J Med 1985;312:334-8. 4. Bard H, Prosmanne J. Relative rates of fetal hemoglobin and adult hemoglobin' synthesis in cord blood of infants of insulin-dependent mothers. Pediatrics 1985;75:1143-7. 5. Bard H, Prosmanne J. Postnatal fetal and adult hemoglobin synthesis in preterm infants who...

Liganded hemoglobin is a stronger acid than ligand-free hemoglobin. The kinetics of the transformation between these states was studied in the pH range 6.9 to 9.0 in 0.3 M NaCl with a pH indicator (phenol red or m-cresol purple) to follow the pH changes accompanying flash photolysis of human carbon monoxide hemoglobin. At least three distinct processes involving protons were detected kineticall...

Technical Appendix Figure. Histopathologic changes associated with a 1918 type II pneumococcal pneumonia case and DNA sequence of a portion of the hemoglobin beta gene. A) Hematoxylin and eosin (H&E)–stained lung showing severe acute bacterial pneumonia with tissue necrosis (original magnification ×40). B) Brown and Hopps tissue Gram stained– lung showing abundant gram-positive cocci consistent...

This study examined whether neuronal hemoglobin (Hb) is present in rats. It then examined whether cerebral ischemia or ischemic preconditioning (IPC) affects neuronal Hb levels in vivo and in vitro. In vivo, male Sprague-Dawley rats were subjected to either 15 mins of transient middle cerebral artery occlusion (MCAO) with 24 h of reperfusion, an IPC stimulus, or 24 h of permanent MCAO (pMCAO), ...

the ingested nitrates sourced from tap water, food, chemicals and pharmaceuticals areconverted to nitrites in the body surfaces by bacteria and then, the nitrite ions can lead thestructural changing in hemoglobin. in the present work, aggregation of the purified hemoglobinin adult (hba) and in fetus or newborn (hbf) in the presence of nitrite ions were studied.hemoglobin aggregation was perform...