OBJECTIVES In the search for neurobiological correlates of depression, a major finding is hyperactivity in limbic-paralimbic regions. However, results so far have been inconsistent, and the stimuli used are often unspecific to depression. This study explored hemodynamic responses of the brain in patients with depression while processing individualized and clinically derived stimuli. METHODS E...

The standard Gaussian function is proposed for the hemodynamic modulation function (HDMF) of functional magnetic resonance imaging (fMRI) time-series. Unlike previously proposed parametric models, the Gaussian model accounts independently for the delay and dispersion of the hemodynamic responses and provides a more flexible and mathematically convenient model. A suboptimal noniterative scheme t...

We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subco...

© 2017 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer Medknow The continued search for the ideal hemodynamic monitoring tool continues. Over time, the medical community has endeavored to identify correlates of hemodynamic status and resultant responses to volume expansion. Historically, we have pursued the use of physical examination alone (jugular he...

Hemodynamic responses that control blood pressure and the distribution of blood flow to different organs are essential for survival. Shear forces generated by blood flow regulate hemodynamic responses, but the molecular and genetic basis for such regulation is not known. The transcription factor KLF2 is activated by fluid shear stress in cultured endothelial cells, where it regulates a large nu...

The hemodynamic responses to isometric exercise (hand grip) were investigated in normotensive subjects during a 150 mEq (n = 8) sodium diet and a 10 mEq (n = 6) sodium diet both before and after the administration of the converting enzyme inhibitor teprotide. Although teprotide significantly decreased the mean arterial pressure during both sodium intakes, the normal pattern of hemodynamic respo...

Functional magnetic resonance imaging was used to investigate hemodynamic responses to adjectives pronounced in happy and angry intonations of varying emotional intensity. In separate sessions, participants judged the emotional valence of either intonation or semantics. To disentangle effects of emotional prosodic intensity from confounding acoustic parameters, mean and variability of volume an...

BACKGROUND To determine if the GlideScope® videolaryngoscope (GVL) could attenuate the hemodynamic responses to orotracheal intubation compared with conventional Macintosh laryngoscope. OBJECTIVES The aim of this relatively large randomized trial was to compare the hemodynamic stress responses during laryngoscopy and tracheal intubation using GVL versus MCL amongst healthy adult individuals r...

BACKGROUND Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can...