The importance of dissecting signaling pathways governing cell differentiation is based on their relevance not only for understanding basic biological phenomena but also better comprehending the underlying mechanisms pathologic alterations such as cancer. A paradigm processes hematopoiesis, where a single stem gives rise to multiple, fully differentiated, lineages. Nucleoredoxin (Nrx), member t...

UHRF proteins catalyze the ubiquitination of target and are involved in regulating gene expression. Some studies reported a reduced expression UHRF2 acute leukemia cells, but role hematopoiesis remains unknown. Here, we generated Uhrf2−/− mice to clarify deletion hematopoiesis. Compared Uhrf2+/+ mice, showed no differences complete blood counts, as well bone marrow (BM) findings spleen weights....